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. 2024 Jan 11;12:RP87607. doi: 10.7554/eLife.87607

Figure 3. Mutation expression clustering of cells from hepatocellular carcinoma (HCC) and its benign liver counterpart.

(A) Uniform Manifold Approximation and Projection (UMAP) clustering of cells from the HCC and benign liver, based on mutational gene expressions shares with standard deviations ≥ 0.4. Red cells are from HCC; Blue cells are from benign liver. (B) UMAP clustering of cells from the HCC and benign liver based on mutational isoform expression shares with standard deviations ≥ 0.4. (C) Relabeling of clusters from (B) as ‘A’, ‘B’, and ‘C’. (D) Venn diagram of mutational isoform expressions in cells from clusters A, B, and C. (E) UMAP clustering of cells from the HCC and benign liver based on the mutational isoform expressions from clusters A, B, and C. (F) UMAP clustering of cells from the HCC and benign liver based on the mutational isoform expression in at least five cells from clusters A, B, and C.

Figure 3.

Figure 3—figure supplement 1. Heatmaps of mutational gene expression.

Figure 3—figure supplement 1.

(A) Heatmap of mutational gene expression share with standard deviations ≥ 0.4. Cells from the hepatocellular carcinoma (HCC) and benign liver are indicated. (B) Heatmap of mutational isoform expression shares with standard deviation ≥ 0.4. Cells from the HCC and benign liver are indicated.