Figure 4. Mutations in human leukocyte antigen (HLA) molecules dominated the landscape of hepatocellular carcinoma (HCC) mutational isoform expressions.

(A) The Uniform Manifold Approximation and Projection (UMAP) clusters from Figure 2F are relabeled as A–H groups as indicated. Cells from HCC and benign liver in each cluster are indicated. (B) Heatmap of 104 mutational isoform expressions in the HCC and benign liver and clusters A–H. (C) Relabeling of UMAP clusters from (A), with cells expressing mutation HLA isoforms in triangles. Cells expressing mutation HLA isoforms in each cluster are indicated.