Table 1.
Resting state functional connectivity (rsFC) changes with iTBS/Sham iTBS (two seeds - left dorsolateral prefrontal cortex or L. dlPFC and right insular cortex to all voxels).
| Seed Region | Between Conditions Contrast Applied | Voxel Number | MNI coordinates | T Statistic | Beta* |
|---|---|---|---|---|---|
| Changes in seed -voxel rsFC between rs-fMRI Time 2 and rs-fMRI Time 3 (n=5) | |||||
| L. dlPFC | GLM (rs-fMRI Time 1, rs-fMRI Time 2, rs-fMRI Time 3; 0, 1, -1) (n=5) | 96 | (+6, -2, -24) bilateral medial prefrontal cortex, bilateral temporal poles, and pons. | 28.87 | 0.18 |
| R. Insula | GLM (rs-fMRI Time 1, rs-fMRI Time 2, rs-fMRI Time 3; 0, 1, -1) (n=5) | 49 | (+30, -92, -10) right occipital pole and inferior division of right lateral occipital cortex | 15.40 | 0.29 |
| Changes in seed -voxel rsFC between rs-fMRI Time 1 and rs-fMRI Time 2 (n=8) | |||||
| L. dlPFC | GLM (rs-fMRI Time 1, rs-fMRI Time 2; -1,1 (n=8)) | 79 | (+14, +50, +22) right frontal pole and right paracingulate gyrus | 10.75 | 0.21 |
| R. Insula | GLM (rs-fMRI Time 1, rs-fMRI Time 2; -1,1 (n=8)) | 64 | (+24, -20, +66) right precentral gyrus and right postcentral gyrus | 9.34 | 0.15 |
| 61 | (-40, -14, +34) left precentral gyrus and left postcentral gyrus | 11.18 | 0.15 | ||
| L. dlPFC | GLM (rs-fMRI Time 1, rs-fMRI Time 2;-1,1; ** Fixation on Cigarette Cues AB Time 1, Fixation on Cigarette Cues AB Time 2; -1,1), (n=8) | No significant results | |||
| R. Insula | GLM (rs-fMRI Time 1, rs-fMRI Time 2;-1,1; ** Fixation on Cigarette Cues AB Time 1, Fixation on Cigarette Cues AB Time 2; -1,1), (n=8) | 181 | (-38, -38, +48) right superior parietal lobule, right postcentral gyrus, right anterior division of supramarginal gyrus. | -8.07 | -0.0023 |
| 79 | (+26, -36, +46) left superior parietal lobule, left postcentral gyrus, left anterior division of supramarginal gyrus, left posterior division of supramarginal gyrus. | -12.37 | -0.0018 | ||
rsFC, resting state functional connectivity.
GLM, general linear model.
All results thresholded at false discovery rate (FDR) corrected cluster threshold p value <0.05 and uncorrected voxel threshold p value <0.0001.
*- Beta represents the regression coefficient displaying the average difference in connectivity between two or three conditions (measured with Fisher-transformed correlation coefficients), depending on the comparison being done. Connectivity measured is between the seed (L. dlPFC or right insula) and respective significant voxel cluster in each row.
** - Between-subjects’ contrast.