Table 1. LeuT mutant affinities for leucine and alanine.
Table 1—source data 1. Pdf file with affinity curves for leucine and alanine binding to LeuT and mutants.
elife-87985-table1-data1.docx (225.3KB, docx)
Table 1—source data 2. Excel file containing data for leucine and alanine affinities for LeuT WT and all investigated mutants.
elife-87985-table1-data2.xlsx (17.8KB, xlsx)
| Leucine affinityKd (nM) | n | Alanine affinityKi (µM) | n | |
|---|---|---|---|---|
| WT | 6.9 [6.7; 7.2]A | 4 | 1.61 [1.58; 1.65] | 4 |
| A22V | 5.4 [4.9; 5.9]A | 3 | 1.02 [0.97; 1.08] | 4 |
| A22S | 8.4 [7.7; 9.1]A | 3 | 2.11 [2.05; 2.17] | 4 |
| N27Q | 1590 [1530; 1650] | 3 | 255 [248; 263] | 3 |
| T254S | 5.6 [5.4; 5.8]A | 3 | 1.17 [1.12; 1.21] | 3 |
| N286Q | 1460 [1390; 1540] | 3 | 287 [277; 297] | 3 |
| E290Q | 193 [169; 221] | 4 | 30.0 [28.9; 31.2] | 3 |