| Strain, strain background (Mus musculus) | 
Bone marrow-derived macrophages (BMMs) | 
KOATECH (Gyeonggi-do, South Korea) | 
KOATECH:C5BL/6 | 
 | 
| Genetic reagent (M. musculus) | 
Arrdc5 shRNA | 
This paper | 
 | 
pLKO.1-puro-CMV-tGFP vector (SHC003; Sigma Aldrich) containing target sequence 5’-CCACACCTTTGAACTTCCATTT-3’ | 
| Cell line (Homo sapiens) | 
HeLa | 
American Type Culture Collection (ATCC) | 
ATCC:CCL-2 | 
 | 
| Cell line (H. sapiens) | 
HEK293 | 
American Type Culture Collection (ATCC) | 
ATCC:CRL-1573 | 
 | 
| Cell line (H. sapiens) | 
HEK293T | 
American Type Culture Collection (ATCC) | 
ATCC:CRL-3216 | 
 | 
| Cell line (Drosophila melanogaster) | 
S2R+ | 
Drosophila Genomics Resource Center (DGRC) | 
DGRC:Stock number 150 | 
 | 
| Antibody | 
TXNIP (D5F3E) Rabbit mAb | 
Cell Signaling Technology | 
Cell signaling:14715 | 
 | 
| Antibody | 
HDAC2 (D6S5P) Rabbit mAb | 
Cell Signaling Technology | 
Cell signaling:57156 | 
 | 
| Antibody | 
Histone H3ac (pan-acetyl) antibody (pAb) 100 µl | 
Active Motif | 
Active Motif:39139 | 
 | 
| Antibody | 
normal rabbit IgG | 
Santa Cruz Biotechnology | 
Santa Cruz:sc-2027 | 
 | 
| Antibody | 
Rabbit TrueBlot: Anti-Rabbit IgG HRP | 
RockLand | 
RockLand:18-8816-31 | 
 | 
| Antibody | 
Monoclonal Anti-ATP6V1A, (C-terminal) antibody produced in mouse, clone 4 F5, purified immunoglobulin, buffered aqueous solution | 
Sigma Aldrich | 
Sigma Aldrich:SAB1402125-100UG | 
 | 
| Antibody | 
Goat anti-Mouse IgM (Heavy chain) Cross-Adsorbed Secondary Antibody, Alexa Fluor 594 | 
Invitrogen | 
Invitrogen:A-21044 | 
 | 
| Antibody | 
Rabbit Anti-Mouse IgG H&L (HRP) | 
Abcam | 
Abcam:ab6728 | 
 | 
| Antibody | 
Goat Anti-Rabbit IgG H&L (HRP) | 
Abcam | 
Abcam:ab6721 | 
 | 
| Antibody | 
α-Tubulin (DM1A) Mouse mAb | 
Cell Signaling Technology | 
Cell Signaling:3873 | 
 | 
| Antibody | 
Fluorescein (FITC) AffiniPure Donkey Anti-Rabbit IgG (H+L) | 
Jackson ImmunoResearch Laboratories | 
Jackson ImmunoResearch:711-095-152 | 
 | 
| Antibody | 
Cy3 AffiniPure Donkey Anti-Rabbit IgG (H+L) | 
Jackson ImmunoResearch Laboratories | 
Jackson ImmunoResearch:711-165-152 | 
 | 
| Antibody | 
HDAC2 Antibody | 
Cell Signaling Technology | 
Cell Signaling:2540 | 
 | 
| Antibody | 
GAPDH (D16H11) XP Rabbit mAb | 
Cell Signaling Technology | 
Cell Signaling:5174 | 
 | 
| Antibody | 
Lamin B1 (D9V6H) Rabbit mAb | 
Cell Signaling Technology | 
Cell Signaling:13435 | 
 | 
| Antibody | 
Phospho-HDAC2 (Ser394) (E8O2Z) Rabbit mAb | 
Cell Signaling Technology | 
Cell Signaling:69238 | 
 | 
| Antibody | 
MTA1 (D40D1) XP Rabbit mAb | 
Cell Signaling Technology | 
Cell Signaling:5647 | 
 | 
| Antibody | 
MBD3 (N87) Antibody | 
Cell Signaling Technology | 
Cell Signaling:14540 | 
 | 
| Antibody | 
ATP6V1B2 (D2F9R) Rabbit mAb | 
Cell Signaling Technology | 
Cell Signaling:14617 | 
 | 
| Antibody | 
Anti-rabbit IgG, HRP-linked Antibody | 
Cell Signaling Technology | 
Cell Signaling:7074 S | 
 | 
| Antibody | 
Anti-mouse IgG, HRP-linked Antibody | 
Cell Signaling Technology | 
Cell Signaling:7076 S | 
 | 
| Antibody | 
GAPDH (G-9) | 
Santa Cruz Biotechnology | 
Santa Cruz:sc-365062 | 
 | 
| Recombinant DNA reagent | 
pCR8/GW/TOPO TA cloning kit | 
Thermo Fisher Scientific | 
Thermo Fisher:K250020 | 
 | 
| Recombinant DNA reagent | 
pMK33-Gateway-GFP destination vector | 
Kwon et al., 2013
 
 | 
pMK33 | 
 | 
| Recombinant DNA reagent | 
pHAGE-GFP-Gateway destination vector | 
Other | 
 | 
Gift from Dr. Chanhee Kang at Seoul National University | 
| Recombinant DNA reagent | 
PEIPro DNA transfection reagent | 
VWR international | 
VWR:115010 | 
 | 
| Recombinant DNA reagent | 
Gateway LR Clonase II enzyme mix | 
Thermo Fisher Scientific | 
Thermo Fisher:11791020 | 
 | 
| Sequence-based reagent | 
α-tubulin RT-qPCR primers | 
This paper | 
 | 
"Forward:CTGGACCGCATCTCTGTGTACT;Reverse:GCCAAAAGGACCTGAGCGAACA" | 
| Sequence-based reagent | 
TXNIP RT-qPCR primers | 
This paper | 
 | 
"Forward:GCTCCTCCCTGCTATATGGAT;Reverse:AGTATAAGTCGGTGGTGGCAT" | 
| Sequence-based reagent | 
CD22 RT-qPCR primers | 
This paper | 
 | 
"Forward:GCGCAGCTTGTAATAGTTGGTGC;Reverse:CACATTGGAGGCTGACCGAGTT" | 
| Sequence-based reagent | 
L1CAM RT-qPCR primers | 
This paper | 
 | 
"Forward:TCGCCCTATGTCCACTACACCT;Reverse:ATCCACAGGGTTCTTCTCTGGG" | 
| Sequence-based reagent | 
OTULINL RT-qPCR primers | 
This paper | 
 | 
"Forward:GTGTGGAGGCAGAGGTTGAT;Reverse:ATGCCGCCAAAATAGCTCCT" | 
| Sequence-based reagent | 
PRR5L RT-qPCR primers | 
This paper | 
 | 
"Forward:GCGGCTGTTGAAGAGTGAAC;Reverse:AGCCAGAACCTCAATGCGAT" | 
| Sequence-based reagent | 
SDC3 RT-qPCR primers | 
This paper | 
 | 
"Forward:CTCCTGGACAATGCCATCGACT;Reverse:TGAGCAGTGTGACCAAGAAGGC" | 
| Sequence-based reagent | 
GAPDH1 RT-qPCR primers | 
This paper | 
 | 
"Forward:ATCACCATCTTCCAGGAGCGA;Reverse:CCTTCTCCATGGTGGTGAAGAC" | 
| Sequence-based reagent | 
CD22 ChIP-qPCR primers | 
This paper | 
 | 
"Forward#1:CGCTGGAGAAGTGAGTTCGG;Reverse#1:TCCCTGCCTCCACTGATAGC", "Forward#2:GACGCTGAGATGAGGGTTGG;Reverse#2:TGACTCAGGAGGTTGGCAGA", "Forward#3:TCCCCACTCTTCTCGCTCTC;Reverse#3:ATTTGCGAGGTTGAGGTTGTC" | 
| Sequence-based reagent | 
L1CAM ChIP-qPCR primers | 
This paper | 
 | 
"Forward#1:CAGCTCAGTGCCTCATGGAA;Reverse#1:GAGACTGCTTCCAGAGTGGG", "Forward#2:GGAATGCTTCACTGGGCAAC;Reverse#2:GGGGTAAGAATTCCGGAGCC", "Forward#3:CGTGTCTGAGAAAGGAAGCCA;Reverse#3:CGGCTTATCCCGATCTACCC" | 
| Sequence-based reagent | 
TXNIP siRNA | 
Bioneer (Dajeon, South Korea) | 
 | 
"Sense: 5’-GUCAGUCACUCUCAGCCAUdTdT–3';Anti-sense: 5'-AUGGCUGAGAGUGACUGACdTdT-3'" | 
| Sequence-based reagent | 
AccuTarget Negative control siRNA | 
Bioneer (Dajeon, South Korea) | 
 | 
 | 
| Peptide, recombinant protein | 
Recombinant Human M-CSF | 
PeproTech | 
PeproTech:300–25 | 
 | 
| Peptide, recombinant protein | 
Recombinant Mouse TRANCE/RANK L/TNFSF11 | 
R&D Systems | 
R&D Systems:462-TEC | 
 | 
| Peptide, recombinant protein | 
Bafilomycin A1 | 
Sigma Aldrich | 
Sigma Aldrich:19–148 | 
 | 
| Commercial assay or kit | 
Pierce BCA Protein Assay Kit | 
Thermo Fisher Scientific | 
Thermo Fisher:23225 | 
 | 
| Commercial assay or kit | 
The ChIP-IT High Sensitivity (HS) Kit | 
Active Motif | 
Active Motif:53040 | 
 | 
| Commercial assay or kit | 
Effectene Transfection Reagent | 
Qiagen | 
Qiagen:301425 | 
 | 
| Commercial assay or kit | 
NE-PER Nuclear and Cytoplasmic Extraction Reagents | 
Thermo Fisher Scientific | 
Thermo Fisher:78833 | 
 | 
| Commercial assay or kit | 
Lipofectamine RNAiMAX | 
Invitrogen | 
Invitrogen:13778075 | 
 | 
| Commercial assay or kit | 
CRISPR & MISSION Lentiviral Packaging Mix | 
Sigma Aldrich | 
Sigma Aldrich:SHP002 | 
 | 
| Commercial assay or kit | 
TRAP Staining Kit | 
Cosmo Bio Co., LTD | 
Cosmo Bio:PMC-AK04F-COS | 
 | 
| Commercial assay or kit | 
dentin discs | 
Immunodiagnostic Systems (IDS) | 
IDS:AE-8050 | 
 | 
| Commercial assay or kit | 
ReverTra Ace qPCR RT Kit | 
Toyobo | 
Toyobo:FSQ-101 | 
 | 
| Commercial assay or kit | 
GoScript Reverse Transcriptase | 
Promega | 
Promega:A5001 | 
 | 
| Commercial assay or kit | 
TruSeq Stranded mRNA Sample Prep Kit | 
Illumina | 
Illumina:RS-122–2101 | 
 | 
| Commercial assay or kit | 
SuperScript II reverse transcriptase | 
Invitrogen | 
Invitrogen:18064014 | 
 | 
| Commercial assay or kit | 
Illumina Tagment DNA TDE1 Enzyme and Buffer Kits | 
Illumina | 
Illumina:20034197 | 
 | 
| Commercial assay or kit | 
Nextera DNA Flex kit | 
Illumina | 
Illumina#20018704 | 
 | 
| Commercial assay or kit | 
MinElute PCR purification Kit | 
Qiagen | 
Qiagen#28004 | 
 | 
| Commercial assay or kit | 
Mycoplasma PCR Detection Kit | 
abm | 
abm#G238 | 
 | 
| Commercial assay or kit | 
e-Myco plus Mycoplasma PCR Detecting Kit | 
iNtRON Biotechnology | 
iNtRON#25237 | 
 | 
| Chemical compound, drug | 
Histopaque | 
Sigma Aldrich | 
Sigma Aldrich:1077 | 
 | 
| Software, algorithm | 
SAINTexpress | 
Teo et al., 2014
 
 | 
 | 
Version 3.6.1 | 
| Software, algorithm | 
COMPLEAT | 
Vinayagam et al., 2013
 
 | 
 | 
 | 
| Software, algorithm | 
DAVID | 
Huang et al., 2009a; Huang et al., 2009b 
 | 
 | 
 | 
| Software, algorithm | 
DIOPT | 
Hu et al., 2011
 
 | 
 | 
Version 7.1 | 
| Software, algorithm | 
Cytoscape | 
Shannon et al., 2003
 
 | 
 | 
Version 3.5.1 and 3.8.2 | 
| Software, algorithm | 
ENCODE ATAC-seq pipeline | 
Jin-Wook et al., 2018
 
 | 
 | 
Version 1.9.2 | 
| Software, algorithm | 
FastQC | 
Andrews, 2010
 
 | 
 | 
Version 0.11.8 | 
| Software, algorithm | 
Sickle | 
Joshi and Fass, 2011
 
 | 
 | 
Version 1.33 | 
| Software, algorithm | 
STAR | 
Dobin et al., 2013
 
 | 
 | 
Version 2.5.3a | 
| Software, algorithm | 
RSEM | 
Li and Dewey, 2011
 
 | 
 | 
Version 1.3.1 | 
| Software, algorithm | 
Comet search engine | 
Eng et al., 2013
 
 | 
 | 
 | 
| Software, algorithm | 
T-COFFEE | 
Notredame et al., 2000
 
 | 
 | 
 | 
| Software, algorithm | 
RAxML | 
Stamatakis, 2014
 
 | 
 | 
Version 8.2.11 | 
| Software, algorithm | 
g:Profiler | 
Raudvere et al., 2019
 
 | 
 
 
 | 
 | 
| Software, algorithm | 
REVIGO | 
http://revigo.irb.hr/
 | 
RRID:SCR_005825
 | 
 | 
| Software, algorithm | 
Python | 
https://www.python.org/
 | 
RRID:SCR_008394
 | 
Version 2.7.14 and 3.6.12 | 
| Software, algorithm | 
R | 
https://www.r-project.org/
 | 
RRID:SCR_001905
 | 
Version 4.0.2 |