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. 2024 Mar 4;15:1368853. doi: 10.3389/fendo.2024.1368853

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Copyright © 2024 Liu, Zhu, Liu, Su, Zeng, Fu, Lu, Rao and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MUFAs/PUFAs ameliorate PA-induced ER stress and the expressions of inflammatory genes. (A) The expression of ER stress markers (CHOP, P-eif2α, XBP1, and IRE1α) were examined using immunoblots. (B) Statistical analysis of protein expression levels in Figure (A). (C) The mRNA expression of ER stress markers (Bip, Chop, Grp94, and Fkbp11) was assessed via real-time PCR. (D) The mRNA expression of Tnfα and Il-6 was assessed via real-time PCR. ^# P<0.05, ^## P<0.01, ^### P<0.001, ^#### P<0.0001 vs. vehicle group. ^* P <0.05, ^** P <0.01, ^*** P <0.001, ^**** P <0.0001 vs. PA group. Data are expressed as mean ± SD, (n≥3).