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. 2024 Mar 4;15:1368853. doi: 10.3389/fendo.2024.1368853

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Copyright © 2024 Liu, Zhu, Liu, Su, Zeng, Fu, Lu, Rao and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High-dose fish oil/olive oil diets improve HFD induced insulin resistance in obese mice. (A) Fasting blood glucose (FBG). (B) Fasting blood Insulin (FBI). (C) HE staining and immunofluorescence Insulin/DAPI staining of mouse pancreatic tissue (200X). (D) Islet area statistics. (E) Intraperitoneal glucose tolerance test (IPGTT) and the area under the curve (AUC) of IPGTT. (F) Intraperitoneal insulin tolerance test (IPITT) and AUC of IPITT. (G) Glucagon/Insulin/DAPI immunofluorescence staining of mouse pancreatic tissues. (H) The ration of α cell/β cell area ^# P<0.05, ^## P<0.01, ^### P<0.001 vs. CHOW group. ^* P<0.05, ^** P<0.01, ^*** P<0.001, ^**** P<0.0001 vs. HFD group. Data are expressed as the mean ± SD, (n≥5).