Table 2.
Baseline characteristics in the validation cohort.
| Group 1 |
Group 2 |
Group 3 |
Group 4 |
|||
|---|---|---|---|---|---|---|
| No event | Bleeding event | Thrombotic event | Both bleeding and thrombotic events | P value | Missing (%) | |
| Number | 2066 | 114 | 31 | 4 | ||
| Age | 66.36 (12.32) | 69.23 (12.64) | 67.03 (11.03) | 54.75 (13.55) | 0.023 | 0.1 |
| Age ≥ 75 years | 586 (28.4) | 47 (41.2) | 8 (25.8) | 0 (0.0) | 0.015 | 0.1 |
| Female sex | 434 (21.0) | 31 (27.2) | 4 (12.9) | 0 (0.0) | 0.183 | 0 |
| Body mass index | 24.10 (3.79) | 23.81 (3.43) | 24.61 (3.12) | 29.95 (4.55) | 0.113 | 4.3 |
| Patient history | ||||||
| Diabetes mellitus | 656 (33.1) | 37 (34.6) | 9 (31.0) | 3 (75.0) | 0.347 | 4.2 |
| Hypertension | 1286 (65.1) | 78 (71.6) | 17 (63.0) | 1 (25.0) | 0.183 | 4.5 |
| Dyslipidaemia | 892 (45.7) | 44 (41.5) | 12 (44.4) | 2 (50.0) | 0.86 | 5.7 |
| Smoking history | 1288 (66.3) | 61 (62.2) | 25 (80.6) | 3 (100.0) | 0.164 | 6.3 |
| Cerebrovascular disease | 181 (9.5) | 8 (7.6) | 2 (6.5) | 1 (25.0) | 0.599 | 7.6 |
| Cancer | 162 (8.5) | 16 (15.2) | 1 (3.2) | 0 (0.0) | 0.064 | 7.6 |
| Previous MI or PCI | 250 (12.4) | 12 (10.7) | 3 (9.7) | 0 (0.0) | 0.787 | 2.7 |
| ST elevation myocardial infarction | 1748 (87.1) | 77 (92.8) | 26 (89.7) | 3 (100.0) | 0.401 | 4.2 |
| Q wave myocardial infarction | 752 (37.8) | 35 (39.3) | 7 (22.6) | 1 (33.3) | 0.369 | 4.7 |
| Culprit vessel | ||||||
| Right coronary artery | 671 (36.0) | 33 (30.8) | 8 (25.8) | 2 (50.0) | 0.42 | 9.3 |
| Left anterior descending artery | 879 (47.1) | 49 (45.8) | 18 (58.1) | 2 (50.0) | 0.666 | 9.3 |
| Left circumflex artery | 296 (15.9) | 12 (11.2) | 3 (9.7) | 0 (0.0) | 0.358 | 9.3 |
| Left main trunk | 59 (3.2) | 19 (17.8) | 1 (3.2) | 0 (0.0) | <0.001 | 9.3 |
| Killip classification III or IV | 243 (11.8) | 77 (67.5) | 3 (9.7) | 3 (75.0) | <0.001 | 0 |
| Thrombolysis | 8 (0.4) | 0 (0.0) | 1 (3.3) | 0 (0.0) | 0.09 | 4.5 |
| IABP | 439 (21.2) | 86 (75.4) | 14 (45.2) | 4 (100.0) | <0.001 | 0 |
| PCPS | 98 (4.7) | 61 (53.5) | 1 (3.2) | 3 (75.0) | <0.001 | 0 |
| Peak creatine kinase | 2903.54 (3182.42) | 7703.67 (12,295.63) | 2896.14 (2275.93) | 13,216.00 (7652.28) | <0.001 | 2.1 |
| Peak creatine kinase myocardial band | 286.31 (648.75) | 515.90 (469.28) | 438.91 (829.08) | 794.35 (341.95) | 0.001 | 2.2 |
| Atrial fibrillation | 134 (6.7) | 11 (12.1) | 1 (3.4) | 0 (0.0) | 0.196 | 3.8 |
| Creatinine clearance <60 mL/min | 730 (36.2) | 55 (53.9) | 9 (29.0) | 1 (33.3) | 0.003 | 2.9 |
| Anemia | 565 (27.4) | 52 (45.6) | 4 (12.9) | 0 (0.0) | <0.001 | 0.2 |
| Heart failure | 392 (19.0) | 66 (57.9) | 11 (35.5) | 2 (50.0) | <0.001 | 0 |
| Antiplatelets | 1863 (98.0) | 57 (98.3) | 28 (100.0) | 2 (100.0) | 0.889 | 10.2 |
| Anticoagulants | 238 (12.5) | 17 (29.3) | 3 (10.7) | 0 (0.0) | 0.002 | 10.2 |
Data are presented as number (percentage) or mean (standard deviation) with listwise deletion. Abbreviations: IABP, intra-aortic balloon pumping; MI, myocardial infarction; PCI, percutaneous coronary intervention; PCPS, percutaneous cardio-pulmonary support.