Table 3.
Histologic characteristics of the established NAFLD and NASH mice (n=5 for each group).
| Parameters | Control | NAFLD | C-NASH | M-NASH | ||||
|---|---|---|---|---|---|---|---|---|
| Normoxia | Hypoxia | Normoxia | Hypoxia | Normoxia | Hypoxia | Normoxia | Hypoxia | |
| Steatosis grade (0-3) | 0 | 0 | 1.28 ± 0.42# | 1.12 ± 0.34# | 2.13 ± 0.37# | 2.24 ± 0.38# | 2.73 ± 0.32# | 2.84 ± 0.36# |
| Lobular inflammation (0-3) | 0 | 0.13 ± 0.10 | 0.16 ± 0.03 | 0.38 ± 0.12# | 0.79 ± 0.22# | 1.34 ± 0.28*# | 1.06 ± 0.26# | 1.95 ± 0.18*# |
| Ballooning score (0-2) | 0 | 0 | 1.00 ± 0.00# | 1.52 ± 0.34*# | 2.00 ± 0.00# | 2.00 ± 0.00# | 2.00 ± 0.00# | 2.00 ± 0.00# |
| NAS grade (0-8) | 0 | 0.13 ± 0.10 | 2.38 ± 0.72# | 2.97 ± 0.83# | 5.08 ± 1.24# | 5.64 ± 0.62# | 5.71 ± 1.16# | 6.28 ± 0.52# |
| Portal inflammation (0-3) | 0 | 0 | 0.16 ± 0.03 | 0.28 ± 0.12# | 0.59 ± 0.12# | 0.94 ± 0.11*# | 1.46 ± 0.1# | 1.95 ± 0.12*# |
| Fibrosis stage (0-4) | 0 | 0 | 0.11 ± 0.02 | 0.58 ± 0.05*# | 1.12 ± 0.24# | 2.23 ± 0.36*# | 2.28 ± 0.18# | 3.02 ± 0.42*# |
On-way analysis of variance: *p < 0.05 between the two groups under the same conditions; #p < 0.05 vs control group.