Table 4.
General characteristics of the NAFLD and NASH mice (n=5 for each group).
| Parameters | Control | NAFLD | C-NASH | M-NASH | ||||
|---|---|---|---|---|---|---|---|---|
| Normoxia | Hypoxia | Normoxia | Hypoxia | Normoxia | Hypoxia | Normoxia | Hypoxia | |
| Weight (g) | 22.02 ± 0.63 | 25.74 ± 0.58 | 27.05 ± 4.15# | 25.81 ± 1.77 | 30.77 ± 2.52# | 26.83 ± 0.63# | 12.38 ± 0.36# | 16.77 ± 0.69# |
| FGB (mmol/L) | 5.73 ± 0.25 | 6.77 ± 0.64 | 5.07 ± 0.35 | 12.97 ± 1.82*# | 6.20 ± 1.11 | 10.23 ± 1.38*# | 4.47 ± 0.67# | 6.53 ± 2.06 |
| Hemoglobin (mg/L) | 189.25 ± 6.85 | 222.25 ± 24.98 | 105.00 ± 8.54# | 145.25 ± 7.68*# | 167.67 ± 2.08 | 231.75 ± 13.38*# | 65.67 ± 24.58# | 109.75 ± 16.82*# |
| Liver Index | 0.03 ± 0.00 | 0.03 ± 0.00 | 0.04 ± 0.00# | 0.04 ± 0.00# | 0.04 ± 0.00# | 0.05 ± 0.00*# | 0.04 ± 0.00# | 0.05 ± 0.00*# |
| Adenosine triphosphate (μmol/L) | 1.60 ± 0.10 | 1.35 ± 0.12*# | 1.79 ± 0.02# | 1.63 ± 0.07* | 1.96 ± 0.10# | 1.79 ± 0.07*# | 1.83 ± 0.12# | 1.42 ± 0.06* |
| Triglycerides (liver)(U/L) | 3.50 ± 0.12 | 3.39 ± 0.38 | 4.20 ± 0.64 | 3.50 ± 0.06 | 9.81 ± 0.56# | 11.98 ± 0.84*# | 9.23 ± 0.13# | 10.44 ± 0.48*# |
| Cholesterol (liver) (U/L) | 15.80 ± 3.06 | 17.98 ± 2.28 | 61.75 ± 5.50# | 55.70 ± 8.08# | 43.66 ± 7.17# | 59.44 ± 12.34*# | 33.67 ± 3.77# | 37.70 ± 12.45# |
| Triglycerides (serum)(μmol/L) | 0.62 ± 0.02 | 0.68 ± 0.04 | 0.85 ± 0.25 | 0.77 ± 0.19 | 0.94 ± 0.09 | 1.61 ± 0.42*# | 1.16 ± 0.21# | 1.37 ± 0.21# |
| Cholesterol (serum) (μmol/L) |
0.79 ± 0.15 | 0.95 ± 0.13 | 2.94 ± 0.94# | 3.07 ± 0.55# | 2.07 ± 0.33# | 3.59 ± 1.13*# | 1.55 ± 0.25 | 1.89 ± 0.60# |
| ALT (serum) (U/L) | 25.67 ± 3.82 | 31.88 ± 1.93 | 52.90 ± 5.57# | 80.11 ± 6.02*# | 116.63 ± 4.96# | 161.51 ± 9.91*# | 95.26 ± 7.11# | 140.34 ± 11.32*# |
| AST (serum) (U/L) | 27.31 ± 2.85 | 31.99 ± 1.77 | 52.36 ± 3.80# | 65.85 ± 4.78*# | 113.74 ± 4.21# | 149.31 ± 4.63*# | 129.39 ± 4.98# | 165.42 ± 5.11*# |
On-way analysis of variance: *p < 0.05 between the two groups under the same conditions; #p < 0.05 vs control group.