FIG. 6.

XIP expression reduced viral replication in stably transduced HepG2 cells. (a) Transient transfection of BPXIPHepG2 cells with wild-type pCMVHBV and payw1.2 produced lower levels of viral replicative forms than in BPHepG2 cells. The relaxed circular (RC), double-stranded linear (DL), and single-strand (SS) DNA species are indicated by arrows on the left. (b) There was no change in the levels of HBV replicative forms after transfection of the two cell lines with HBx-deficient payw*7, or in the levels of DHBV viral replication after transfection with plasmid pDHBV3, as measured by hybridization with a full-length DHBV probe.