Table 3.
Linear regression analysis of factors associated with CD4+ T cell count among HIV-positive and-negative participants
| Variables | No. (%) of study participants | ||||
|---|---|---|---|---|---|
| HIV positive | HIV negative | ||||
|
aUnadjusted β (95% CI), p-value |
bAdjusted β (95% CI), p value |
aUnadjusted β (95% CI), p-value |
bAdjusted β (95% CI), p-value |
||
| Gender, female n (%) | 1.85(-55.24 to 58.94), p = 0.949 | – | 60.23(16.94 to 103.53), p < 0.007 | 53.79(14.41 to 93.17), p = 0.008 | |
| Age (in years) | − 3.88(− 6.48 to − 1.27), p = 0.004 | − 1.60(− 4.56 to 1.35), p = 283 | − 2.78(− 4.91 to − 0.64), p = 0.011 | − 2.11(− 4.06 to − 0.15), p = 0.035 | |
| Residence | |||||
| Rural | 1 | 1 | |||
| Urban | 25.08(− 44.18 to 94.34), p = 0.476 | – | 23.52(− 37.97 to 85.01), p = 449 | – | |
| Marital status | |||||
| Single | 1 | 1 | |||
| Married | − 5.32(− 68.32 to 57.68), p = 0.868 | – | 13.46(− 34.82 to 61.75), p = 0.581 | – | |
| Divorced/widowed | 41.86(− 44.8 to 128.52), p = 0.342 | – | 39.89(− 31.89 to 111.67), p = 0.272 | – | |
| Education level | |||||
| Illiterate | 1 | 1 | 1 | ||
| Elementary school | 14.75(− 48.19 to 77.68), p = 0.644 | 11.37(− 63.12 to 85.87), p = 0.762 | 39.77(− 12.16 to 91.70), p = 0.132 | – | |
| Secondary school and above | 105.61(15.76 to 195.46), p = 0.020 | 84.0(− 14.56 to 182.56), p = 0.094 | 43.97(− 28.27 to 116.21), p = 230 | – | |
| Monthly income level | |||||
| Low | 1 | 1 | 1 | ||
| Middle | − 23.02(− 84.97 to 38.92), p = 0.464 | 28.60(− 50.71 to 107.91), p = 0.475 | − 6.72(− 58.86 to 45.42), p = 0.798 | – | |
| High | 113.28(38.62 to 187.93), p = 0.003 | 66.34(− 17.49 to 150.18), p = 119 | − 29.18(− 87.81 to 29.45), p = 0.325 | ||
| BMI (kg/m2) | 43.72(36.05 to 51.38), p < 0.001 | 18.77(6.21 to 31.33), p = 0.004 | 11.32(1.89 to 20.75), p = 0.019 | 8.50(− 0.17 to 17.17), p = 0.054 | |
| H. pylori infection | |||||
| Negative | 1 | 1 | 1 | 1 | |
| Positive | 86.77(31.19 to 142.36), p = 0.002 | 69.54(11.70 to 127.37), p = 0.019 | 75.89(33.79 to 117.99), p < 0.001 | 64.77(25.37 to 104.16), p = 0.002 | |
| Alcohol intake | |||||
| No | 1 | 1 | |||
| Yes | 5.25(− 59.25 to 69.76), p = 0.873 | – | 13.06(− 35.31 to 61.42), p = 0.593 | – | |
| Smoking habit | |||||
| No | 1 | 1 | |||
| Yes | 15.8(− 57.28 to 88.88), p = 0.670 | – | − 38.28(− 97.73 to 21.17), p = 0.204 | – | |
| Khat chewing habit | |||||
| No | 1 | 1 | 1 | ||
| Yes | − 132.79(− 222.59 to − 43.0), p = 0.004 | − 36.00(− 128.17 to 56.16), p = 0.439 | − 0.99(− 90.52 to 88.54), p = 0.983 | – | |
| WHO clinical stage of HIV | |||||
| Stage I | 1 | 1 | N/A | ||
| Stage II | − 243.03(− 311.57 to − 174.5), p < 0.001 | − 204.81(− 273.7 to − 135.92), p < 0.001 | N/A | ||
| Stage III | − 360.01(− 439.5 to − 280.51), p < 0.001 | − 224.96(− 332.33 to − 117.60), p < 0.001 | N/A | ||
| Stage IV | − 453.77(− 566.97 to − 340.57), p < 0.001 | − 213.01(− 379.38 to − 46.64), p = 0.013 | N/A | ||
| HIV-1 viral load (copies/mL) | |||||
| < 10,000 | 1 | 1 | N/A | ||
| 10,000–100,000 | − 247.39(− 295.9 to − 198.88), p < 0.001 | − 140.06(− 241.55 to − 38.56), p = 0.007 | N/A | ||
| > 10,0000 | − 311.78(− 355.29 to − 268.27), p < 0.001 | − 211.13(− 451 to 29.22), p = 0.084 | N/A | ||
| ART status | |||||
| ART-Naïve | 1 | – | N/A | ||
| On ART | 161.07(109.33 to 212.81), p < 0.001 | – | N/A | ||
| Duration of ART | 1.34(0.24 to 2.44), p = 0.018 | 0.93(0.04 to 1.82), p = 0.04 | |||
| Duration of ART | |||||
| < 3 years | 1 | N/A | |||
| ≥ 3 years | 151.94 (67.06 to 236.82), p < 0.001 | 82.06 (− 5.78 to 169.89), p = 0.067 | N/A | ||
H. pylori Helicobacter pylori, HIV human immunodeficiency virus, ART antiretroviral therapy, β regression coefficient, CI confidence interval, 1 = reference category
aLinear regression analysis
bMultiple regression adjusted for factors with p value ≤ 0.05 by linear regression analysis