Table 1.
Heterogeneity and pleiotropy analysis of immune cell with AD using different analytical methods
| Exposure | Cochran Q statistic (MR Egger) | Heterogeneity p-value (MR Egger) | Pleiotropy p-value (MR Egger) | PRESSO global outlier test | |
|---|---|---|---|---|---|
| RSSOBs | p-value (Robust adjusted Profile Score) | ||||
| CD4 Treg AC | 11.090 | 0.921 | 0.936 | 12.467 | 0.948 |
| CD38 on IgD- CD38br | 8.512 | 0.744 | 0.242 | 10.431 | 0.804 |
| IgD on IgD + CD24+ | 28.109 | 0.255 | 0.940 | 32.406 | 0.303 |
| IgD on IgD + CD38br | 26.647 | 0.225 | 0.078 | 34.551 | 0.162 |
| IgD on IgD+ | 16.074 | 0.652 | 0.104 | 24.573 | 0.446 |
| CD3 on CM CD8br | 10.055 | 0.758 | 0.328 | 12.235 | 0.8 |
| HVEM on T cell | 23.258 | 0.330 | 0.649 | 26.114 | 0.397 |
| CD28 on CD45RA- CD4 not Treg | 7.822 | 0.729 | 0.788 | 8.897 | 0.847 |
| HLA DR on CD14- CD16 + monocyte | 13.644 | 0.692 | 0.584 | 14.712 | 0.803 |
| HLA DR on CD14 + CD16- monocyte | 22.086 | 0.336 | 0.803 | 24.543 | 0.431 |
| HLA DR on CD14 + monocyte | 21.405 | 0.315 | 0.810 | 23.895 | 0.383 |
| SSC-A on HLA DR + CD8br | 24.474 | 0.323 | 0.309 | 28.438 | 0.343 |