Table 2.

Effects of DGAT1/2 inhibitors on tumor cell growth

Type of tumor	Inhibition of DGATs	Effects on tumor cell growth
Glioblastoma	DGAT1 inhibitor (A-922500)	Suppressed cell proliferation. Induced cell apoptosis and upregulation of CPT1A protein [96, 104, 105]
	Inhibition of DGAT1 by shRNA or miRNA-3918	Increased sensitivity of irradiation and prolonged survival of mice [141]
Melanoma	DGAT1 inhibitors (AZD3988, AZD7687, A922500, or T863)	Suppressed cell proliferation and cell cycle progression. Increased the expression of cleaved caspase-3 protein [121]
Gastric cancer	DGAT1 inhibitor (A-922500)	Reduced cell proliferation. Induced apoptosis [147]
Prostate cancer	Inhibition of DGAT1 by siRNA or A-922500	Reduced cell proliferation. Induced of cell cycle G1 arrest and autophagy [122] [116]
Breast cancer (MCF-7 cells)	DGAT2 inhibitor (PF-06424439)	Inhibited cell proliferation. Induced cell cycle G2/M arrest. Increased sensitivity of radiation. Reduced cell invasive ability. Reduced LD formation [35, 123, 124] Increased the production of ROS and unrepaired DNA damage of tumor cells after irradiation [123]
Breast cancer (MDA-231 cells)	DGAT1 inhibitor (A-922500)	Reduced cell proliferation and migratory ability [124]
Ovarian cancer	Knockdown of DGAT1	Inhibited cell proliferation. Reduced cell migration through modulating the EMT process [38]
Gastric cancer	Knockdown of DGAT2	Reduced mesenteric metastatic nodules in the intestinal wall and lung metastasis [39]
Colon cancer	DGAT1 inhibitor (A922500) and DGAT2 inhibitor (PF-06424439)	Inhibition of DGAT1 and DGAT2 decreased tumor growth and reduced the proportion of CD206 + MHCII low immunosuppressive myeloid cells in the tumors [150]