Table 2.
Ordinal logistic regression analysis assessing factors associated with voriconazole levels below or above the target range
| Below target range | Above target range | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate OR (95% CI) |
P value | Multivariate OR (95% CI) |
P value | Univariate OR (95% CI) |
P value | Multivariate OR (95% CI) |
P value | |
| Age | 0.99 (0.97–1.01) |
0.293 | 1.02 (0.98–1.06) |
0.379 | ||||
| Sex | 0.71 (0.35–1.45) |
0.342 | 1.63 (0.55–4.85) |
0.38 | ||||
| ECMO | 3.44 (1.65–7.18) |
0.001 | 4.59 (1.73–12.2) |
0.002 | 0.79 (0.2–3.12) |
0.741 | ||
| Renal replacement therapy | 1.55 (0.76–3.19) |
0.228 | 0.85 (0.25–2.95) |
0.798 | ||||
| Immunosuppression | 0.93 (0.47–1.86) |
0.84 | 0.54 (0.16–1.86) |
0.33 | ||||
| Tx | 1.39 (0.64–3.01) |
0.403 | 0.79 (0.2–3.13) |
0.741 | ||||
| —Tacrolimus | 2.1 (0.83–5.4) |
0.118 | 1.12 (0.22–5.88) |
0.889 | ||||
| —Mycophenolate mofetil | 1.56 (0.47–5.2) |
0.464 | 0.88 (0.1–8.1) |
0.910 | ||||
| —Prednisolone | 1.19 (0.57–2.5) |
0.646 | 0.63 (0.16–2.46) |
0.508 | ||||
| INRa | 0.68 (0.54–0.86) |
0.001 | 0.6 (0.41–0.87) |
0.007 | 1.08 (0.88–1.31) |
0.469 | ||
| Bilirubinb | 0.98 (0.93–1.03) |
0.417 | 1.02 (0.97–1.08) |
0.442 | ||||
| MELD score | 0.99 (0.98–1) |
0.674 | 0.99 (0.93–1.06) |
0.836 | ||||
| Leukocytes | 0.99 (0.98–1.01) |
0.896 | 0.91 (0.84–1) |
0.049 | 0.92 (0.82–1.03) |
0.144 | ||
| PCT | 0.93 (0.86–1.01) |
0.072 | 0.99 (0.97–1.03) |
0.968 | ||||
| CRP | 0.99 (0.99–1) |
0.066 | 0.99 (0.99–1) |
0.485 | ||||
| ALT | 0.99 (0.99–1) |
0.129 | 0.99 (0.99–1) |
0.697 | ||||
| AST | 0.99 (0.99–1) |
0.037 | 0.99 (0.99–1) |
0.019 | 0.99 (0.99–1) |
0.434 | ||
| Serum albumin | 1.89 (1.18–2.76) |
0.008 | 1.67 (0.91–3.06) |
0.098 | 1.35 (0.64–2.86) |
0.426 | ||
Statistically significant values are in bold.
Tx, transplanted; PCT, procalcitonin; CRP, C-reactive protein; ALT, alanine-aminotransferase.
aValue changes by 0.1.
bValue changes per 10 mmol/L.