Enantioselectivity in Friedel-crafts reactions catalysed by SCP_Q111BpyAla mutant ArMs.
| |||
|---|---|---|---|
| Entry | Mutant of SCP_Q111BpyAla | Yield of 5a (%) | e.r.b (R : S) |
| 1 | None | 43 (±2) | 14 : 86 (±1) |
| 2 | Q108A | 38 (±7) | 28 : 72 (±0) |
| 3 | V82A | 33 (±2) | 24 : 76 (±1) |
| 4 | F34A | 21 (±1) | 31 : 69 (±0) |
| 5 | M112A | 33 (±4) | 19 : 81 (±0) |
| 6 | K115A | 41 (±5) | 27 : 73 (±1) |
| 7 | D88A | 54 (±10) | 18 : 82 (±1) |
a
Yield obtained by HPLC using 2-phenylquinoline as internal standard; standard deviations are shown in brackets.
b
e.r. determined using chiral HPLC.