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Models for Sall4 functions in PM development. (A) Sall4 contributes to multiple aspects of PSM development and somite development. (B) Sall4-dependent open chromatin status drives repression and activation of negative regulators and positive regulators, respectively, of WNT signaling. (C) Sall4-dependent open chromatin status contributes to repression of neural gene expression in the mesoderm, by facilitating CTCF binding.
