Table 1.
Baseline and Clinical Characteristics of Patients with ALL and Matched Comparators
| ALL (n=154) | Comparators (n=770) | |
|---|---|---|
| Age group, n (%) | ||
| 18–30 | 67 (43.5) | 335 (43.5) |
| 31–40 | 26 (16.9) | 130 (16.9) |
| 41–50 | 32 (20.8) | 160 (20.8) |
| 51–60 | 29 (18.8) | 145 (18.8) |
| Sex, n (%) | ||
| Male | 100 (64.9) | 500 (64.9) |
| Female | 54 (35.1) | 270 (35.1) |
| Cohabiting status, n (%) | ||
| Living alone | 53 (34.4) | 257 (33.4) |
| Living with partner | 101 (65.6) | 502 (65.2) |
| Unknown | 0 (0.0) | 11 (1.4) |
| Education level (ISCED), n (%) | ||
| ISCED 0–2 | 44 (28.6) | 218 (28.3) |
| ISCED 3 | 74 (48.1) | 321 (41.7) |
| ISCED 5–6 | 24 (15.6) | 142 (18.4) |
| ISCED 7–8 | 12 (7.8) | 67 (8.7) |
| Unknown | 0 (0.0) | 22 (2.9) |
| Equalized income, quartiles, n (%) | ||
| Lowest | 37 (24.0) | 190 (24.7) |
| Second lowest | 40 (26.0) | 169 (21.9) |
| Second highest | 39 (25.3) | 200 (26.0) |
| Highest | 38 (24.7) | 196 (25.5) |
| Unknown | 0 (0.0) | 15 (1.9) |
| Employment status, n (%) | ||
| Working* | 132 (85.7) | 673 (87.4) |
| Unemployed/Flexible job | 14 (9.1) | 70 (9.1) |
| Sick leave | 8 (5.2) | 15 (1.9) |
| Unknown | 0 (0.0) | 12 (1.6) |
| Long-term sickness, n (%)** | ||
| No | 130 (84.4) | 736 (95.6) |
| Yes | 24 (15.6) | 34 (4.4) |
| CCI prior to diagnosis, n (%) | ||
| 0 | 122 (79.2) | 610 (79.2) |
| ≥1 | 32 (20.8) | 160 (20.8) |
| ECOG Performance status, n (%) | ||
| 0 | 84 (54.5) | - |
| ≥1 | 70 (45.5) | - |
| ALL immunophenotype, n (%) | ||
| T-ALL | 40 (26.0) | - |
| B-ALL | 114 (74.0) | - |
| Treatment***, n (%) | ||
| High-intensity | 55 (35.7) | - |
| Standard intensity/Other | 44 (28.6) | - |
| Transplantation | 55 (35.7) | - |
| Year of diagnosis, n (%) | ||
| 2005–2009 | 38 (24.7) | - |
| 2010–2014 | 53 (34.4) | - |
| 2015–2019 | 63 (40.9) | - |
Notes: *Working group including receipt of state education grant, leave of absence, and parental leave. **4 or more consecutive weeks of sick leave within the last year before diagnosis (patients) or corresponding date (comparators). ***High-intensity: NOPHO ALL-2008 protocol, no transplantation. Standard intensity: All other curative intended regimens, no transplantation. Transplantation: All transplanted patients regardless of other treatment regimens.
Abbreviations: ISCED, International Standard Classification of Education; CCI, Charlson Comorbidity Index; ECOG, Eastern Cooperative Oncology Group.