TABLE 2.
Secondary outcomes.
| Freeze‐dried plasma (n = 9) a | Standard care (n = 11) a | Relative risk or median difference (95% CI) | |
|---|---|---|---|
| Mortality (censored at 24 h) | 1 (11.1) | 5 (45.4) | 0.24 (0.03 to 1.73) |
| Mortality (censored at hospital discharge) | 3 (33.3) | 5 (45.4) | 0.73 (0.24 to 2.27) |
| ICU admission | 6 (66.7) | 6 (54.5) | 1.2 (0.6 to 2.5) |
| Hemoglobin b (g/L) | 101.5 (83 to 125) | 142.5 (126 to 155) | −41.0 (−82.0 to 6.0) |
| Platelet count b (×109/L) | 206 (148.5 to 295.5) | 210.5 (156 to 296) | −4.5 (−318.1 to 300.1) |
| Fibrinogen b (g/L) | 2.0 (1.8 to 2.6) | 2.3 (1.9 to 2.3) | −0.3 (−2.6 to 2.4) |
| INR b | 1.3 (1.2 to 1.4) | 1.3 (1.2 to 1.5) | 0 (−62.9 to 62.9) |
| ≤1.3 | 5 (62.5) | 5 (62.5) | 1.0 (0.28 to 3.54) |
| >1.3 | 3 (37.5) | 3 (37.5) | |
| aPTT b (s) | 30.5 (24.8 to 34.2) | 32 (28.4 to 48.2) | −1.5 (−38.6 to 31.8) |
| Lactate b (mmol/L) | 2.8 (1.7 to 4.5) | 2.8 (1.8 to 6.5) | 0 (−5.0 to 4.6) |
| RBC units in 24 h b | 8 (2 to 8) | 6.5 (1 to 8.5) | 1.5 (−5.8 to 9.8) |
| FFP units in 24 h b | 4 (0 to 7) | 4 (0 to 5.5) | 0 (−5.6 to 5.6) |
| Platelets units in 4 h b , c | 1 (0 to 5) | 1 (0 to 1) | 0 (− 5.2 to 5.2) |
| Cryoprecipitate in 4 h | 0 (0 to 0) | 0 (0 to 0) | 0 (−6.9 to 6.9) |
| Hospital length of stay (days) | 19 (13 to 21) | 9 (0 to 30) | 10 (−14.3 to 34.3) |
| Thromboembolism | 1 (11.1) | 2 (18.2) | 0.61 (0.07 to 5.70) |
Abbreviations: aPTT, activated partial thromboplastin time; FFP, fresh‐frozen plasma; ICU, intensive care unit; INR, international normalized ratio; RBC, red blood cell.
a
Data are reported as median (IQR) or n (%).
b
Among 16 patients who arrived at the hospital.
c
One adult dose is either a platelet unit produced from a pool of buffy coats collected from four whole‐blood donors or an apheresis platelet unit.