TABLE 1.
Summary of previously published two‐sample MR studies for sleep and adiposity traits
| Study | Exposure | Outcome | Sample size (outcome) | Sensitivity analyses | β (95% CI) | p value |
|---|---|---|---|---|---|---|
| Dashti et al., 2021 [ 15 ] | Sleep duration | BMI | 339,224 | No | 0.039 (−0.06 to 0.13) | 4.20 E‐01 |
| Daytime napping | BMI | 339,224 | 0.21 (0.02 to 0.40) | 3.00 E‐02 | ||
| Morning preference | BMI | 339,224 | −0.01 (−0.05 to 0.03) | 5.90 E‐01 | ||
| Daytime sleepiness | BMI | 339,224 | 0.20 (−0.33 to 0.73) | 4.60 E‐01 | ||
| Insomnia | BMI | 339,224 | 0.36 (0.26 to 0.46) | 1.25 E‐12 | ||
| BMI | Sleep duration | 446, 118 | 0.01 (−0.04 to 0.07) | 6.30 E‐01 | ||
| BMI | Daytime napping | 452,633 | 0.03 (0.00 to 0.05) | 4.00 E‐02 | ||
| BMI | Morning preference | 697,828 | 0.06 (0.00 to 0.12) | 4.60 E‐02 | ||
| BMI | Daytime sleepiness | 452,071 | 0.02 (0.01 to 0.03) | 4.00 E‐04 | ||
| BMI | Insomnia | 1,331,010 | 0.01 (−0.01 to 0.03) | 4.20 E‐01 | ||
| Dashti et al., 2021 [ 16 ] | Daytime napping | WC | 232,101 | Limited | 0.28 (0.11 to 0.45) | 1.00 E‐03 |
| Insomnia | WHR | 210,082 | 0.29 (0.17 to 0.41) | 1.58 E‐07 | ||
| Sleep duration | Obesity (clinically determined) | 16,033 | 1.00 (0.99 to 1.00) | 2.40 E‐01 | ||
| WC | Daytime napping | 452,633 | 0.03 (−0.01 to 0.07) | 1.10 E‐01 | ||
| WHR | Insomnia | 1,331,010 | −0.03 (−0.05 to −0.01) | 7.16 E‐07 | ||
| WHR (adj. BMI) | Sleep duration | 446,118 | −0.14 (−0.19 to −0.08) | 5.03 E‐06 | ||
| Wang et al., 2019 [ 17 ] | Sleep duration | Child‐BMI | 35,668 | Limited | −0.29 (−0.54 to −0.04) | 2.20 E‐02 |
Abbreviation: adj., adjusted; child‐BMI, childhood BMI; MR, Mendelian randomization; WC, waist circumference; WHR, waist‐hip ratio.