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. 2023 Sep 1;40(11):e15194. doi: 10.1111/dme.15194

FIGURE 4.

FIGURE 4

Algorithm used for biochemical evaluation of participants with clinically suspected anti‐insulin antibodies. Gel filtration chromatography (GFC); high molecular weight insulin immunoreactivity (HMW IIR); anti‐insulin IgG measurement ([IA]); plasma insulin immunoreactivity (IIR); IIR recovery in supernatant following PEG precipitation and centrifugation of plasma (PEG). Positive GFC results determined if HMW immunoreactivity >3000 pmol/L post‐insulin spike. One participant in Group 2 did not have GFC and was not studied further.