FIGURE 2.

Weighted effects of disease‐modifying therapy (DMT) in relapsing and progressive multiple sclerosis (MS), showing data from the full cohort (including relapsing and progressive MS). Data are from marginal structural models. Weights for the marginal structural model were calculated from a logistic model with treatment status as a dependent variable; independent variables included fixed covariates and the baseline stabilizing variables (sex, MS duration at first visit, date of birth) and time‐dependent covariates (age, pregnancy status, treatment history, history of relapses, MS duration, Expanded Disability Status Scale [EDSS], MS course). The “Overall” rows in the figure display the overall effects of treatment. Hazard ratios (HRs) and p‐values for phenotype (overall) represent the interactions between DMT and disease phonotype. HRs and p‐values for phenotype × ARR represent a three‐way interaction between DMT, phenotype, and annualized relapse rate. The boxes show HRs and p‐values for the interactions between DMT and MS phenotype, and a three‐way interaction among DMT–MS phenotype–ARR. CI, confidence interval