Figure 1.

Design of BLIP2 (in green) interfacing sites. a) Different protein‐CNT interfacing approaches. Potential interface sites using standard amine attachment approaches (top); available lysine residues are shown as orange spheres. Shown are a binding orientation that does not result communication with CNT and another that blocks protein ligand binding (TEM‐1 shown in red, white and blue shades). Defined attachment using bioorthogonal ncAAs (bottom). The dashed purple line represents a putative Debye field length. b) Selected residues for replacement with AzF (see Supporting Scheme SI‐1 for details on incorporation) (PDB code 1jtd ^[11d] ). The AzF models were built as described previously. ^[6b]