FIG. 2.

CD8 T-cell immunotherapy modulates the course of primary CMV infection. Throughout, BMT was performed with 10⁷ BMC and was followed by intraplantar infection (corresponding to Fig. 1, bottom). The group that did not receive immunotherapy served as a reference showing the normal course of infection during reconstitution after BMT (top). In the remaining three groups, immunotherapy was performed by adoptive transfer of the indicated doses of CD8 T cells. Virus titers in organs (ordinate) were monitored as a function of time after BMT and infection (abscissa). The dashed line gives the detection limit of the infectivity assay, which was 100 PFU* per organ. Individual titers are depicted for three mice per time point. The median value is marked by a short horizontal bar. Cases in which virus titers were uniformly negative for an organ are depicted only on the first occasion, but the titers then remained negative throughout the kinetics. Symbols: open circles, salivary glands; solid circles, lungs; solid squares, adrenal glands.