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. 2023 Apr 14;29(29):e202300008. doi: 10.1002/chem.202300008

Scheme 26.

Scheme 26

a) Aggarwal's strain‐release‐driven 1,2‐migration reaction of azabicyclo[1.1.0]butyl boronate complexes (105). b) Application to the synthesis of cobimetinib.