Scheme 32.

Anderson's study into the synthesis and reactivity of bridge lithiated bicyclo[1.1.0]butane. a) Bridge deprotonation and functionalization of bicyclo[1.1.0]butyl amide 128. b) Attempted enantioselective deprotonation of bicyclo[1.1.0]butane bridging methylenes. ^a The identity of the major stereoisomer was not determined. c) Sequential bridge deprotonation and functionalization. d) Application of deuterated bicyclo[1.1.0]butane 131 in the mechanistic study of difluorocarbene insertion.