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. 2022 Nov 9;17(24):e202200400. doi: 10.1002/cmdc.202200400

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© 2022 The Authors. ChemMedChem published by Wiley-VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Panel A&D, control DMSO vehicle‐treated HeLa cells, no compound with images recorded in A the red channel, and D in the green channel. B&E The effects of 100 μM Bis‐T‐22 2 (B, red channel; E, green channel) on the uptake of EGF‐TxR dye in HeLa cells. C&F the effects of 30 μM prodrug 4 (C, red channel; F, green channel) on internalisation of EGF‐Tx in HeLa cells. The control cells show level of autofluorescence in the green channel and the product Bis‐T‐22 is highly fluorescent in the green channel.