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Schematic representation of targeted transmorphic phage/AAV (RGD4C.TPA) encoding the TNFα gene. The RGD4C ligand is displayed on the pIII minor coat proteins of the TPA capsid. A TNFα therapeutic DNA sequence is inserted into a mammalian transgene cassette flanked by the ITR cis‐elements, from AAV2, and downstream a CMV promoter. A phage origin of replication, f1 ori, is the only phage genetic sequence present in the TPA DNA.
