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. 2023 Jan 28;33(4):322–346. doi: 10.1002/hipo.23502

FIGURE 2.

FIGURE 2

Gene expression patterns of APOE and neural progenitor genes crucial for determining hippocampal cell fate from Days 0 to 18/19 of directed differentiation. Real‐time qPCR was performed on isogenic APOE lines (E3, E4, E2, and KO). Expression values of (a) APOE, (b) PAX6, (c) SOX2, (d) EMX2, (e) FOXG1, and (f) NEUROD1 were normalized to GAPDH expression. Day 0 of E3 was used as the reference sample for each gene. Two‐way ANOVA with Bonferroni correction. n = 3. Mean with SD shown. Adjusted p values: 0 < *** < 0.001 < ** < 0.01 < * < 0.05, when each cell line was compared to E3 on each day of directed differentiation.