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. 2023 Jan 28;33(4):322–346. doi: 10.1002/hipo.23502

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© 2023 The Authors. Hippocampus published by Wiley Periodicals LLC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Characterization of proliferation and caspase‐mediated apoptosis from Days 21 to 42 of directed differentiation. Immunocytochemistry for (a) Ki67+ cells (proliferation) and (b) cleaved caspase 3 (CC3) + cells (apoptosis) was performed on APOE lines (E3, E4, E2, and KO). Both markers were normalized against the number of total nuclei. Two‐way ANOVA with Bonferroni correction. n = 5. Mean with SD shown. Adjusted p values: 0 < *** < .001 < ** < .01 < * < .05, when each cell line was compared to E3 on each day of directed differentiation.