TABLE 2.
Correlations between LEAP2 concentrations and cardiometabolic variables
| Variable | Correlations | |
|---|---|---|
| r | P | |
| Demographic and anthropometric measures | ||
| Age (years) | 0.15 | 0.2 |
| Body mass index a (kg/m2) | 0.04 | 0.7 |
| Waist‐hip ratio b | 0.08 | 0.5 |
| Body fat (%) | 0.10 | 0.4 |
| Fat mass (kg) | 0.14 | 0.3 |
| Fat free mass (kg) | 0.03 | 0.8 |
| Glycaemic measures | ||
| Fasting blood glucose (mmol/L) | −0.01 | 0.9 |
| 2‐hour post OGTT blood glucose (mmol/L) | 0.21 | 0.09 |
| Insulin sensitivity (M; mg/kg/min) | −0.22 | 0.07 |
| Fasting insulin by IVGTT a (mlU/L) | 0.39 | 0.001 |
| Total insulin AUC by IVGTT a (mlU/L) | 0.25 | 0.047 |
| First phase insulin AUC by IVGTT a (mlU/L) | 0.28 | 0.02 |
| Second phase insulin AUC by IVGTT a (mlU/L) | 0.25 | 0.04 |
| Cardiovascular measures | ||
| Systolic blood pressure (mmHg) | 0.22 | 0.08 |
| Diastolic blood pressure (mmHg) | 0.29 | 0.02 |
| Heart rate (bpm) | 0.08 | 0.5 |
| Pulse pressure (mmHg) | 0.02 | 0.9 |
| Mean arterial pressure (mmHg) | 0.29 | 0.02 |
| Inflammation markers and Adipokines | ||
| C‐reactive protein b (mg/L) | 0.13 | 0.3 |
| Interleukin‐1β (pg/mL) | −0.22 | 0.07 |
| Nuclear factor kappa‐B (pg/μg protein) | −0.20 | 0.1 |
| Adiponectin a (ng/mL) | −0.10 | 0.4 |
| Adipsin (ng/mL) | 0.04 | 0.8 |
| Leptin a (ng/mL) | 0.03 | 0.8 |
| Resistin b (ng/mL) | 0.02 | 0.8 |
Note: Data were analysed using Pearson correlations unless otherwise indicated. Bold denotes statistical significance.
Abbreviations: AUC, area under the curve; HDL, high‐density lipoprotein cholesterol; IVGTT, intravenous glucose tolerance test; LDL, low‐density lipoprotein cholesterol; OGTT, oral glucose tolerance test.
a
Non‐normal data which were log‐transformed prior to Pearson correlation analysis.
b
Data were analysed using nonparametric Spearman correlation tests.