Table 1.

Cortical μCT Results of Femurs and Lumbar Vertebrae (L₄) Harvested From Naïve Mice Treated With Control or Anti‐LRP6 Antibodies (10 mg/kg) at Days 7 and 14

	Day 7			Day 14
Parameter	Anti‐LRP6 isotype	Anti‐LRP6 Ab	p a	Anti‐LRP6 isotype	Anti‐LRP6 Ab	p b
Femur
Ct.BV (mm3)	0.693 ± 0.026	0.687 ± 0.035	0.687	0.565 ± 0.031	0.629 ± 0.037	0.006
Ct.Th (mm)	0.101 ± 0.004	0.098 ± 0.001	0.132	0.078 ± 0.004	0.083 ± 0.004	0.029
L4
Ct.BV (mm3)	0.347 ± 0.041	0.358 ± 0.034	0.53	0.337 ± 0.033	0.38 ± 0.04	0.06
Ct.Th (mm)	0.072 ± 0.004	0.072 ± 0.002	0.97	0.065 ± 0.001	0.067 ± 0.003	0.26

Note: Results presented as mean ± SD.

Abbreviation: Ab = antibody; Ct.BV = cortical bone volume; Ct.Th = cortical thickness.

^a Unpaired t test between naïve mice treated with anti‐LRP6 isotype versus anti‐LRP6 Ab after 7 days of treatment.

^b Unpaired t test between naïve mice treated with anti‐LRP6 isotype versus anti‐LRP6 ab after 14 days of treatment.