Table 2.

Cortical μCT Results of Femurs and L₄ Vertebrae From Naïve and Myeloma‐Bearing (5TGM1eGFP) Mice Treated With Anti‐LRP6 Isotype or Anti‐LRP6 Antibodies (10 mg/kg) for 21 Days (Experiment 1)

	Naive		5TGM1eGFP
Parameter	Anti‐LRP6 isotype	Anti‐LRP6 Ab	Anti‐LRP6 isotype	Anti‐LRP6 Ab
Femur
Ct.BV (mm3)	0.486 ± 0.019 a	0.489 ± 0.023	0.459 ± 0.047	0.454 ± 0.042
Ct.Th (mm)	0.077 ± 0.002	0.076 ± 0.004	0.08 ± 0.005	0.077 ± 0.006
L4
Ct.BV (mm3)	0.351 ± 0.026	0.361 ± 0.045	0.315 ± 0.045	0.316 ± 0.059
Ct.Th (mm)	0.062 ± 0.001	0.064 ± 0.001	0.06 ± 0.004	0.062 ± 0.003

Note: Results presented as mean ± SD.

Abbreviation: Ab = antibody; Ct.BV = cortical bone volume; Ct.Th = cortical thickness.

^a p < 0.05 between naïve mice treated with anti‐LRP6 isotype versus anti‐LRP6 Ab.