Table 4.

Cortical μCT Results of Femurs and L₄ Vertebrae From Naïve and Myeloma‐Bearing (5TGM1eGFP) Mice Treated With Control or Anti‐LRP6 Antibodies or Anti‐LRP6/DKK1 Isotype or Antibodies (10 mg/kg)

	Naive		5TGM1eGFP
Parameter	Anti‐LRP6 isotype	Anti‐LRP6/DKK1 isotype	Anti‐LRP6 isotype	Anti‐LRP6 Ab	Anti‐LRP6/DKK1 isotype	Anti‐LRP6/DKK1 Ab
Femur
Ct.BV (mm3)	0.613 ± 0.038	0.595 ± 0.019	0.491 ± 0.048a	0.556 ± 0.022e	0.50 ± 0.023f	0.626 ± 0.028
Ct.Th (mm)	0.096 ± 0.003	0.093 ± 0.003	0.084 ± 0.003b,c	0.088 ± 0.001d	0.089 ± 0.003	0.092 ± 0.002
L4
Ct.BV (mm3)	0.316 ± 0.022	0.323 ± 0.022	0.293 ± 0.034	0.318 ± 0.042	0.285 ± 0.016g	0.356 ± 0.041
Ct.Th (mm)	0.068 ± 0.003	0.066 ± 0.002	0.064 ± 0.003	0.065 ± 0.004i	0.062 ± 0.001h	0.072 ± 0.003

Note: Results presented as mean ± SD.

Abbreviation: Ab = antibody; Ct.BV = cortical bone volume; Ct.Th = cortical thickness.

^a,b p < 0.05 compared to 5TGM1 + Anti‐LRP6 Ab mice; ^c p < 0.05 compared to 5TGM1 + Anti‐LRP6/DKK1 Ab mice; ^d p < 0.05 compared to 5TGM1 + Anti‐LRP6/DKK1 Ab mice; ^e p < 0.001 compared to 5TGM1 + Anti‐LRP6/DKK1 Ab mice; ^f p < 0.001 compared to 5TGM1 + Anti‐LRP6/DKK1 Ab mice; ^g,h p < 0.001 compared to 5TGM1 + Anti‐LRP6/DKK1 Ab mice; ⁱ p < 0.05 compared to 5TGM1 + Anti‐LRP6/DKK1 Ab mice.