Table 2.
Examination findings
| Study parameter | No. (%) |
|---|---|
|
| |
| Fundus examinations | 283 |
| Abnormal fundus examinations (possibly related) | 44 (15.5) |
| Not attributable to vigabatrin | 40 (14.1) |
| Inconclusive | 4(1.4) |
| Attributable to vigabatrin | 0 (0) |
| ERG | 37 |
| Abnormal ERG | 12 (32.4) |
| Not attributable to vigabatrin | 10 (27.0) |
| Inconclusive | 0 (0) |
| Attributable to vigabatrin | 2 (5.4) |
| OCT | 19 |
| Abnormal OCT | 3 (15.8) |
| Not attributable to vigabatrin | 3 (15.8) |
| Inconclusive | 0 (0) |
| Attributable to vigabatrin | 0 (0) |
| Visual Fields | 6 |
| Abnormal Visual Fields | 2 (33.3) |
| Not attributable to vigabatrin | 2 (33.3) |
| Inconclusive | 0(0) |
| Attributable to vigabatrin | 0 (0) |
| Examination findings UNRELATED to vigabatrin | 283 |
| Cortical visual impairment | 81 (28.6) |
| Strabismus | 63 (22.3) |
| Non-medication-related retinal lesionsa | 31 (10.9) |
| Optic atrophy | 37 (13.1) |
| Optic nerve hypoplasia | 10 (3.5) |
| Other optic nerve | 6(2.1) |
| VF deficit | 9 (3.2) |
| Otherb | 38 (13.4) |
| No abnormality | 37 (13.1) |
ERG, electroretinogram; OCT, optical coherence tomography.
a
Retinal changes included: lacunae, hamartoma, congenital hypertrophy of the retinal pigment epithelium (CHRPE), bear tracks, astrocytoma, laser scars, retinal detachment, fungal chorioretinitis, non-medication-related retinal pigment changes.
b
Other included nystagmus, pigment, cataract, microphthalmos, nasolacrimal duct obstruction, corneal abrasion or ulcer, corneal scar or opacity, exposure keratopathy, anisocoria, retrolental membrane, subconjunctival hemorrhage, glaucoma, persistent fetal vasculature, iris hypopigmentation, iris coloboma.