Figure 4.

Human GPX4 (C66S) in complex with ML162 (S enantiomer). The surface of GPX4 with bound (S)‐ML162 (depicted with yellow carbons) (PDB entry 6HKQ) was superimposed to a structure that shows the peptide inhibitor GXpep3 (depicted with green carbons) bound to GPX4 (U46C) (PDB entry 5h5s). The surface of the catalytic tetrad is colored red (Sec46), blue (Gln81), dark blue (Trp136), and purple (Asn137). Two different orientations are shown. Reproduced with permission of the International Union of Crystallography. ¹⁷⁷  GPX4, glutathione peroxidase 4; PDB, Protein Data Bank. [Color figure can be viewed at wileyonlinelibrary.com]