Table 3.

Comparison of Serum EVs from Healthy and Patient Samples from CD9-IC with a Standard Mixture of Cancer Cells^a

No	Genes	Accessions	MixedStd	Normal serum	HCC serum	Pan serum
1	CD9	P21926	6.3	-	5.1	-
2	CD81	P60033	6.2	-	-	-
3	ANXA2	P07355	5.9	3.4	4.5	3.2
4	LGALS3BP	Q08380	5.4	4.9	-	5.0
5	SDCBP	O000560	5.4	-	5.3	-
6	ITGB1	P05556	5.3	4.1	4.7	-
7	FN1	P02751	5.1	6.4	5.0	6.5
8	VIM	P08670	5.1	-	4.2	-
9	PDCD6IP	Q8WUM4	5.1	3.1	-	-
10	ANXA1	P04083	5.1	-	4.5	-
11	ANXA4	P09525	5.1	4.7	-	-
12	ANXA11	P50995	5.0	-	4.4	-
13	ANXA7	P20073	5.0	-	4.6	-
14	TFRC	P02786	5.0	4.8	6.2	4.4
15	ANXA5	P08758	4.9	4.9	3.7	-
16	ANXA6	P08133	4.8	-	-	-
17	LYZ	P61626	4.7	4.6	4.4	-
18	PF4	P02776	4.7	4.9	5.4	5.8
19	ANXA3	P12429	4.6	-	-	-
20	CD63	P08962	4.5	-	3.9	-
21	ALDH1A1	P00352	4.5	-	4.9	4.2
22	NT5E	P21589	4.4	-	-	-
23	TSG101	Q99816	4.4	-	-	-
24	SDC1	P18827	4.3	-	-	-
25	MAPRE2	Q15555	4.3	-	-	-
26	ALDH1A3	P47895	4.2	-	5.9	4.8
27	CDH1	P12830	4.1	-	-	-
28	ALDH1L1	O75891	4.1	-	-	-
29	ALDH2	P05091	4.1	-	-	-
30	HGFAC	Q04756	4.0	4.9	-	4.8
31	ALDH18A1	P54886	4.0	-	-	-
32	ALDH7A1	P49419	4.0	-	5.3	-
33	ALDH3A2	P51648	4.0	-	4.7	3.7
34	ALDH3A1	P30838	3.9	-	-	-
35	ALDH16A1	Q8IZ83	3.9	-	-	-
36	PARVB	Q9HBI1	3.9	-	-	-
37	ALDH9A1	P49189	3.9	-	-	-
38	ALDH3B1	P43353	3.8	-	-	-
39	CDH2	P19022	3.7	-	-	-
40	PLEK	P08567	3.6	-	5.1	-
41	CDH11	P55287	3.1	-	-	-
42	CDH5	P33151	-	4.5	-	4.4

^aA total of 42 EV markers were detected with varying levels of abundance. Abundance values were shown in Log10 scale and ranked from the highest to the lowest in mixed standard sample.