Table 2.
Changes in molecules found in a mouse model of radiation followed by wounding, burning, or hemorrhage trauma.
| Molecule | RI + WND | RI + Burn | RI + Hemo | Molecule | RI + WND | RI + burn | RI + Hemo |
|---|---|---|---|---|---|---|---|
| NF-κB | ↑ | ND | ↑ | MCP-1 | ↑ | ND | ↑ |
| STAT3 | ↑ | ND | ↑ | MIP-1α/β | ↑ | ND | ↑ |
| iNOS | ↑ | ND | ↑ | IFN-γ | — | ND | — |
| Claudin-2 | ↑ | ND | ND | Rantes | — | ND | — |
| IL-1β | ↑ | ND | ↑ | AKT | ↓ | ND | — |
| IL-3 | — | ND | ↑ | MAPK | ↑ | ND | ↑ |
| IL-6 | ↑ | ND | ↑ | CRP | ↑ | ↓ | ↓ |
| KC (i.e., IL-8) | ↑ | ND | ↑ | C3 | ↑ | ↑ | ↑ |
| IL-10 | ↑ | ND | ↑ | Corticosterone | ↑ | ↑ | ↑ |
| IL-12p70 | ↑ | ND | ↑ | IgM | ↓ | ↓ | ↑ |
| IL-13 | ↑ | ND | ↑ | PGE2 | ↑ | ↑ | — |
| IL-18 | ↑ | ND | ↑ | ATP | ↑ | ↑ | ↑ |
| TNF-α | ↑ | ND | ↑ | miR-34 | ↑ | ND | ↑ |
| G-CSF | ↑ | ND | — | Caspase-3 | ↑ | ND | ↑ |
| GM-CSF | ↑ | ND | ↑ | Flt-3L | ↑ | ND | ↑ |
| Exotaxin | ↑ | ND | ↑ | Citrulline | ↓ | ND | ND |
NF-κB: Nuclear factor-keppa B; STAT3: Signal transducer and activator of transcription 3; iNOS: inducible nitric oxide synthase; IL-interlukin; KC: Keratinocyte chemoattractant; TNF: Tumor necrosis factor; G-CSF: Granulocyte-colony stimulating factor; GM-CSF: Granulocyte-Macrophage-colony stimulating factor; MCP-1: Monocyte chemoattractant protein-1; MIP-1: Macrophage inflammatory protein; IFN: Interferon; AKT: Protein kinase B; MAPK: Mitogen-activated protein kinase; CRP: C-reactive protein; C3: Complement component 3; IgM: Immunoglobulin M; PGE2: Prostaglandin E2; ATP: Adrine trisphophate; miR: MicroRNA; Flt-3L: Fms-like tyrosine kinase 3 ligand; RI: Radiation Injury; WND: Wound; Hemo: Hemorrhage; ↑: Increase; ND: Not done; ↓: Decrease;—:Not different from radiation alone.