Table 2. Relevance of Enhanced CT, ⁶⁸Ga-PSMA-11 PET/CT and ¹⁸F-FDG PET/CT Parameters for Identification of Pathological Characteristics in ccRCC.

Pathological features		Radiological parameters
		Enhanced CT			68Ga-PSMA-11 PET/CT			18F-FDG PET/CT
		CT value	ICCa	Pb value	SUVmax	ICCa	Pc value	SUVmax	ICCa	Pc value
Tumor necrosis				0.221			<0.001			0.119
	Negative	128.97± 31.86	0.936 [0.895-0.961]		17.39 (7.58-25.20)	0.969 [0.949-0.982]		3.97 (2.98-6.40)	0.906 [0.848-0.943]
	Positive	141.08±32.87	0.929 [0.787-0.961]		30.51 (26.18-32.54)	0.898 [0.679-0.968]		5.92 (3.32-6.81)	0.922 [0.767-0.975]
Sarcomatoid or rhabdoid feature				0.262			<0.001			0.038
	Negative	129.86 32.66	0.937 [0.899-0.961]		18.76 (8.91-26.93)	0.971 [0.952-0.982]		4.02 (3.03-6.79)	0.907 [0.852-0.942]
	Positive	145.33± 23.48	0.895 [0.477-0.984]		33.93 (32.54-35.33)	0.837 [0.195-0.976]		6.79 (5.45-8.04)	0.914 [0.537-0.987]
Adverse pathology *				0.179			<0.001			0.049
	Negative	128.31±32.63	0.937 [0.894-0.962]		14.94 (7.36-23.32)	0.967 [0.944-0.981]		3.69 (2.94-6.40)	0.915 [0.859-0.949]
	Positive	140.35± 29.63	0.927 [0.811-0.973]		31.55 (27.87-34.39)	0.869 [0.683-0.950]		5.59 (4.52-6.81)	0.900 [0.745-0.963]

^*Adverse pathology is defined as tumor presenting with necrosis or a sarcomatoid or rhabdoid feature

^aICC: Data in the brackets are 95% confidence intervals

^bP values were calculated with Student's t test

^cP values were calculated with Mann-Whitney U test

ccRCC = clear-cell renal cell carcinoma; CT = computed tomography; ICC = Intraclass correlation coefficient; SUV_max = maximum standardized uptake value

Data are mean ± standard deviation for CT value, median (interquartile range) for SUV_max