Fig. 2.

Effect of pendrin/NCC double KO on agonist-induced aorta contraction. a Contractile responses of ring segments from pendrin/NCC double KO (closed bar) and wild type (open bar) to 50 mM KCl, 1 μM phenylephrine (PE), and 0.1 μM U46619 were expressed as millinewton/millimete r (mN/mm) vessel length. Number in parenthesis represents number of mice in each case. b, c Concentration-contraction curves of aorta to phenylephrine (n = 6 in each case) and U46619 (n = 5 in each case), respectively, from pendrin/NCC double KO (open circle plus dashed line) and wild type (closed circle plus uninterrupted line) were determined from the experiments in a and expressed as percent maximal contraction. *p < .05