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. Author manuscript; available in PMC: 2024 Mar 18.
Published in final edited form as: Kidney Blood Press Res. 2017 Jul 27;42(3):444–455. doi: 10.1159/000479296

Fig. 2.

Fig. 2.

Kidney expression of renin and AQP-2 in response to HCTZ. (A and B) Northern blot analysis of renin mRNA expression in WT and pendrin KO mice kidney after HCTZ treatment indicate significant increase of renin expression in pendrin KO post-treatment of HCTZ compared to WT mice. (C and D) Western blot analysis of renin expression in pendrin KO mice before and after HCTZ indicates an increase in renin expression following HCTZ treatment (n=3/group); * P<0.05. Western blot analysis of total AQP2 and Ser256p-AQP2 in kidneys of experimental animals indicates a significant reduction in Ser256P-AQP2 in pendrin KO mice treated with HCTZ vs. untreated pendrin KO mice (E and F).