Table 3:
Effects of clinical characteristics on change in six-minute walk distance and maximal treadmill walking time in response to supervised treadmill exercise vs. control in people with PAD*
| Subgroup | Change in six minute walk distance (meters) in the exercise group relative to the control group (changes by subgroup) | Change in maximal treadmill walk time (minutes) in the exercise group relative to the control group (changes by subgroup) | ||||||
|---|---|---|---|---|---|---|---|---|
| Absolute change | Percentage change | Absolute change | Percentage change | |||||
| Absolute change difference, (95% CI) | P value for interaction | Percentage change difference, (95% CI) | P value for interaction | Absolute change difference, (95% CI) | P value for interaction | Percentage change difference, (95% CI) | P value for interaction | |
| Age ≥67 vs. <67 years | −10.3 (−38.9, 18.4) | 0.48 | −4.8% (−16.8%, 7.3%) | 0.43 | +1.5 (−0.2, 3.3) | 0.084 | 2.0% (−44.2%, 48.2%) | 0.93 |
| Females vs. males | +15.8 (−12.8, 44.4) | 0.28 | 8.1% (−3.9%, 20.1%) | 0.18 | −0.5 (−2.2, 1.3) | 0.60 | 14.6% (−32.0%, 61.1%) | 0.54 |
| Blacks vs. whites | −1.1 (−30.3, 28.0) | 0.94 | 2.9% (−9.4%, 15.2%) | 0.64 | −0.7 (−2.5, 1.1) | 0.42 | 1.8% (−45.5%, 49.1%) | 0.94 |
| Ankle brachial index ≥0.65 vs. <0.65 | −4.0 (−32.5, 24.4) | 0.78 | −2.6% (−14.6%, 9.5%) | 0.68 | −0.3 (−2.1, 1.4) | 0.72 | −47.6% (−92.8%, −2.3%) | 0.039 |
| Body mass index (≥30 vs. <30 kg/m 2 ) | +1.5 (−27.1, 30.0) | 0.92 | 2.0% (−10.0%, 14.0%) | 0.74 | −1.8 (−3.5, −0.1) | 0.036 | −33.1% (−79.1%, 13.0%) | 0.16 |
| Current smoker | 20.9 (−10.4, 52.2) | 0.19 | 3.6% (−9.6%, 16.9%) | 0.59 | −0.2 (−2.1, 1.7) | 0.86 | 16.4% (−34.5%, 67.3%) | 0.53 |
| Diabetes | 12.6 (−16.8, 42.0) | 0.40 | 7.2% (−5.2%, 19.6%) | 0.25 | 1.4 (−0.4, 3.2) | 0.12 | 42.4% (−5.0%, 89.9%) | 0.080 |
| Coronary artery disease | −18.0 (−49.9, 13.8) | 0.27 | −8.0% (−21.4%, 5.4%) | 0.24 | −1.7 (−3.6, 0.2) | 0.082 | −38.5% (−89.2%, 12.2%) | 0.14 |
| Pulmonary disease | 19.3 (−26.8, 65.5) | 0.41 | 7.0% (−12.5%, 26.5%) | 0.48 | −1.3 (−4.1, 1.4) | 0.34 | −31.4% (−105.4%, 42.6%) | 0.40 |
| Heart Failure | −43.2 (−91.8, 5.4) | 0.081 | −14.9% (−35.4%, 5.6%) | 0.15 | 0.4 (−2.5, 3.2) | 0.81 | 0.3% (−76.1%, 76.7%) | 0.99 |
| Classic symptoms of intermittent claudication | −13.1 (−43.4, 17.3) | 0.40 | −5.0% (−17.8%, 7.8%) | 0.44 | 1.4 (−0.5, 3.2) | 0.15 | 27.3% (−21.6%, 76.3%) | 0.27 |
| Asymptomatic (report of no exertional leg symptoms) | 2.3 (−63.9, 68.6) | 0.95 | −1.8% (−29.8%, 26.1%) | 0.90 | −0.1 (−4.3, 4.1) | 0.96 | −63.9% (−175.0%, 47.1%) | 0.26 |
| History of lower extremity revascularization | 9.1 (−22.2, 40.3) | 0.57 | 1.0% (−12.1%, 14.2%) | 0.88 | −0.1 (−2.0, 1.8) | 0.92 | 26.2% (−24.4%, 76.8%) | 0.31 |