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. Author manuscript; available in PMC: 2024 Mar 18.
Published in final edited form as: Kidney Int. 2008 May 21;74(4):438–447. doi: 10.1038/ki.2008.184

Figure 2 |. Effect of fructose on fluid (salt) absorption in Slc26a6 and Glut5 mutant mice.

Figure 2 |

(a) Basal and fructose-induced jejunal fluid absorption in Slc26a6+/+ and Slc26a6−/− mice. Basal rates were reduced by ~25% in Slc26a6−/− mice as compared with Slc26a6+/+ littermates. 40 mM fructose elicited ~67% increase in fluid absorption in Slc26a6+/+ mice but only ~39% in Slc26a6−/− mice. #P<0.01 as compared with NaCl control. (b) Fructose-induced jejunal fluid absorption in Slc26a6+/+ and Slc26a6−/− mice. The magnitude of fructose-stimulated fluid absorption was B110% higher in Slc26a6+/+ mice as compared with Slc26a6−/− mice. *P<0.05 compared with wild-type control. Results are mean ± s.e.m. (c) The role of chloride ion in basal and fructose-stimulated fluid absorption. After basal period measurement in the presence of NaCl, jejunum was perfused with iso-osmolar chloride-free (150 mM Na gluconate) solution. Chloride removal inhibited basal fluid absorption by 75%. Replacement of 40 mM gluconate completely blocked the fructose-stimulated fluid absorption in normal mouse jejunum. *P<0.05 compared with NaCl control.