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Disease Burden Score
| Size of largest tumor lesion | Number of metastatic lesions ≥ 1 cm in size | Number of sites involved* |
|---|---|---|
| ≤ 2.5 cm; 0 points | ≤ 3; 0 point | 1; 0 point |
| > 2.5 cm, ≤ 5 cm; 1 point | >3, ≤ 6; 1 point | 2–3; 1 point |
| > 5 cm; 3 points | > 6; 3 points | 4 or more; 3 points |
Scoring:
Total score ≤ 2, small disease burden
Total score ≥ 3, large disease burden
Sites: CNS (brain and spine), head/neck (not CNS), chest, abdomen, pelvis, upper extremity, lower extremity
