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. Author manuscript; available in PMC: 2024 Sep 15.
Published in final edited form as: Cancer Res. 2024 Mar 15;84(6):887–904. doi: 10.1158/0008-5472.CAN-23-1908

Figure 3. R-loop resolution genes are upregulated in PARPi-resistant BRCAm HGSOC patients.

Figure 3.

A, Scheme for generating the list of R-loop regulators identified by published proteomic studies. B, mRNA expression levels of R-loop resolution genes in PARPi-sensitive (PEO1, UWB1.289) and PARPi-resistant HGSOC cell lines (PEO1/OlaR, PEO1/OlaJR, UWB/OlaR) were analyzed by qPCR (n = 3). C, Venn diagram showing the overlap of upregulated R-loop regulators in PARPi-resistant BRCAm HGSOC cells. Data were analyzed using one-way ANOVA test and shown as mean ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001.