Table 2.

Univariable and multivariable analysis

Univariable analysis	Crude OR	(95%CI)	p-value
Gestational age (wk)	1.26	(0.98–1.62)	0.07
Cross-clamp time (min)	0.98	(0.96–1.00)	0.02*
Post-CPB salvaged blood (ml/kg)	1.04	(1.01–1.08)	0.01*
Post-CPB cryoprecipitate (ml/kg)	1.09	(1.02–1.16)	0.01*
Post-CPB platelet (ml/kg)	1.04	(1.01–1.08)	0.03*
Post-CPB transfused volume (ml/kg)	1.03	(1.01–1.05)	0.009*
Fluid balance POD1 (ml/kg)	1.00	(1.00–1.01)	0.03*
RBC transfusion POD1	4.52	(0.95–21.42)	0.06
Postoperative to 24hr minimum Hb	0.67	(0.49–0.92)	0.01*
P/F ratio ICU admission	1.00	(1.00–1.01)	0.03*
24-hour P/F ratio	0.99	(0.98–1.00)	0.02*
24-hour P/F ratio <300	6.38	(1.34–30.27)	0.02*
P/F ratio <200 at ICU admission	0.31	(0.13–0.76)	0.01*
Multivariable analysis	Adjusted OR	95%CI	p-value
Ventilation ≥ 48 hours †
24-hour P/F ratio < 300	3.49	0.81–19.73	0.157
Post-CPB salvaged blood (ml/kg)	1.04	0.98–1.10	0.148
Post-CPB platelet (ml/kg)	1.00	0.94–1.08	0.805
Post-CPB cryoprecipitate (ml/kg)	1.06	0.96–1.17	0.256
POD1 fluid balance	1.01	0.99–1.02	0.069
Gestational age (wk)	0.55	0.62–0.99	0.05
Acute lung injury †
Post CPB salvaged blood (ml/kg)	1.04	0.97–1.03	0.971
Post CPB platelet (ml/kg)	1.04	1.00–1.08	0.042*
Post CPB cryoprecipitate (ml/kg)	0.96	0.91–1.01	0.150
Logistic regression model for ventilation ≥ 48 hours
24-hour P/F ratio < 300	6.33	1.26–32.62	0.025*
Post CPB salvaged blood (ml/kg)	1.04	1.00–1.09	0.033*
POD1 fluid balance	1.01	0.99–1.01	0.152
Area under ROC curve = 0.795

^*Represents statistical significance

^†Post-CPB transfused volume was omitted because of collinearity.

Abbreviations: CPB, cardiopulmonary bypass; PRC, packed red cells; POD, postoperative day; Hb, hemoglobin; P/F ratio, PaO₂/FiO₂ ratio