Table 1.
Patient-level and nodule-level descriptive statistics for each of the four screening cohorts included in this study. Means and standard deviations are reported for numeric variables and counts and proportions are reported for categorical variables.
| Total Participants (N = 6,865) | ||||
|---|---|---|---|---|
| IELCAP-Toronto (n = 502) |
NLST (n = 3,743) |
PanCan (n = 1,785) |
PLuSS (n = 835) |
|
| No. lung cancers (%) | 12 (2.4%) | 336 (9.0%) | 40 (2.2%) | 51 (6.1%) |
| Age (years) | 62.8 [7.5] | 62.4 [5.3] | 63.2 [6.0] | 60.5 [7.0] |
| Sex | ||||
| Male | 194 (38.6%) | 2,149 (57.4%) | 953 (53.4%) | 426 (51.0%) |
| Female | 308 (61.4%) | 1,594 (42.6%) | 832 (46.6%) | 309 (49.0%) |
| Body mass index (kg/m2) | 26.4 [4.4] | 27.5 [4.9] | 26.6 [4.5] | 28.1 [5.3] |
| Family history of lung cancer | ||||
| No | 388 (77.3%) | 2,894 (77.3%) | 1,288 (72.2%) | 190 (82.6%) |
| Yes | 114 (22.7%) | 849 (22.7%) | 497 (27.8%) | 145 (17.4%) |
| History of COPD or Emphysema | ||||
| No | 430 (85.7%) | 3,232 (86.3%) | 1,496 (83.8%) | 740 (88.6%) |
| Yes | 72 (14.3%) | 511 (13.7%) | 289 (16.2%) | 95(11.4%) |
| Smoking status | ||||
| Current | 66 (13.1%) | 1,845 (49.3%) | 1,133 (63.5%) | 580 (69.5%) |
| Former | 436 (86.9%) | 1,898 (50.7%) | 652 (36.5%) | 255 (30.5%) |
| Years smoked | 30.6 [10.7] | 40.9 [7.5] | 42.6 [8.8] | 40.9 [7.9] |
| Cigarettes per day | 21.3 [9.9] | 28.4 [11.4] | 24.7 [10.5] | 25.9 [9.8] |
| Years since cessation | 14.5 [10.6] | 19.9 [20.3] | 2.6 [5.7] | 2.0 [3.5] |
| Total Nodules (N = 16,797) | ||||
| IELCAP-Toronto (n = 1,062) |
NLST (n = 6,108) |
PanCan (n = 8,422) |
PLuSS (n = 1,205) |
|
| Nodules per participant | 3.2 [2.0] | 2.4 [1.7] | 8.0 [5.2] | 2.0 [1.4] |
| Nodule solidity | ||||
| Solid | 783 (74%) | 4,585 (79%) | 6,015 (80%) | 1,042 (86%) |
| Subsolid | 277 (26%) | 1,199 (21%) | 1,503 (20%) | 163 (14%) |
| Major axis length (mm) | 9.1 [5.2] | 11.0 [8.7] | 5.5 [4.5] | 12.5 [8.0] |
| Least axis length (mm) | 5.2 [2.7] | 5.8 [3.8] | 2.6 [2.4] | 6.6 [3.9] |
| Mesh Volume (mm3) | 446.5 [2,172.8] | 872.1 [5,202.0] | 168.4 [1,914.6] | 1,171.8 [6,489.3] |
| Sphericity | 0.76 [0.08] | 0.73 [0.10] | 0.79 [0.08] | 0.72 [0.09] |
Abbreviations: COPD, chronic obstructive pulmonary disease; IELCAP, International Early Lung Cancer Action Plan; mm, millimeter; NLST, National Lung Screening Trial; No., number; PanCan, PanCanadian Early Detection of Lung Cancer Study; PLuSS, Pittsburgh Lung Screening Study.