Table 2:

Association of diabetes status with left atrial function, Atherosclerosis Risk in Communities Study, 2011-13 (n=5075, 1196 normal fasting glucose, 2239 prediabetes, 1640 diabetes)^*

LA strain	Diabetes status	Model 1†		Model 2‡		Model 3§
		Beta (95% CI)*	P-value	Beta (95% CI)*	P-value	Beta (95% CI)*	P-value
LA reservoir strain, %	Normal	Reference
	Prediabetes	−0.59 (−1.19, 0.01)	0.053	−0.17 (−0.74, 0.40)	0.558	−0.33 (−0.86, 0.20)	0.217
	Diabetes	−2.29 (−2.93, −1.64)	<0.001	−0.41 (−1.05, 0.24)	0.215	−0.43 (−1.03, 0.16)	0.156
LA conduit strain, %	Normal	Reference
	Prediabetes	−0.76 (−1.14, −0.38)	<0.001	−0.48 (−0.87, −0.09)	0.015	−0.47 (−0.85, −0.09)	0.016
	Diabetes	−1.81 (−2.21, −1.40)	<0.001	−0.89 (−1.33, −0.45)	<0.001	−0.68 (−1.11, −0.25)	0.002
LA contractile strain, %	Normal	Reference
	Prediabetes	0.19 (−0.26, 0.64)	0.404	0.33 (−0.11, 0.77)	0.139	0.17 (−0.25, 0.58)	0.429
	Diabetes	−0.42 (−0.91, 0.06)	0.087	0.52 (0.02, 1.01)	0.041	0.30 (−0.16, 0.76)	0.201

^*Beta-coefficient represents difference in LA strain (%) for diabetes and prediabetes groups compared to no diabetes group (referent)

^†Model 1: Age, Sex, Race by Clinic site, and Educational attainment

^‡Model 2: Model 1 + Systolic blood pressure, Body mass index, Smoking, Heart failure, Coronary heart disease, Atrial fibrillation, Estimated glomerular filtration rate cystatin C, high-sensitivity C-reactive protein, and anti-hypertensive use

^§Model 3: Model 2 + Left atrial volume index, Left ventricular mass index, Left ventricular filling pressures (E/e’)