Table A.1.
Participant Characteristics and Bup Treatment Continuation at Post-hospital Follow-up, 30 days and 90 days* Among Patients with OUD, N = 22
| Patient-related characteristics | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Bupe rx at follow-up n = 10 | No bupe rx at followup n = 12 | p-value | Bupe rx 30 days n = 8 | No bupe rx 30 days n = 14 | p-value | Bupe rx 90 days n = 8 | No bupe rx 90 days n = 14 | p-value | |
| Age: median (IQR) | 56 (46, 59) | 44 (40, 61) | NS | 57 (66, 47) | 46 (40, 60) | NS | 57 (47, 66) | 46 (40, 60) | NS |
| Gender (man) | 5 (50.0) | 7 (58.3) | NS | 5 (62.5) | 7 (50.0) | NS | 5 (62.5) | 7 (50.0) | NS |
| Race (white) | 7 (70.0) | 11 (91.7) | NS | 7 (87.5) | 11 (78.6) | NS | 7 (87.5) | 11 (78.6) | NS |
| Ethnicity Latino/a/x (yes) | 6 (60.0) | 4 (33.3) | NS | 4 (50.0) | 8(57.1) | NS | 4 (50.0) | 8(57.1) | NS |
| Insurance Type Medicaid | 6 (60.0) | 7 (58.3) | NS | 4 (50.0) | 9 (64.3) | NS | 4 (50.0) | 9 (64.3) | NS |
| Stably Housed (yes) | 7 (70.0) | 8 (66.7) | NS | 7 (87.5) | 8(57.1) | NS | 7 (87.5) | 8(57.1) | NS |
| Mental Health Diagnosis (yes) | 7 (70.0) | 7 (58.3) | NS | 6 (75.0) | 8(57.1) | NS | 6 (75.0) | 8(57.1) | NS |
| Prior bupe rx (yes) | 7 (70.0) | 5 (41.7) | NS | 5 (62.5) | 7 (50.0) | NS | 5 (62.5) | 7 (50.0) | NS |
| History of Precipitated Withdrawal (yes) | 2 (20.0) | 3 (25.0) | NS | 2 (25.0) | 3 (21.4) | NS | 2 (25.0) | 3 (21.4) | NS |
| Primary Opioid Used | |||||||||
| Rx opioids | 3 (30.0) | 4 (33.3) | NS | 3 (37.5) | 4 (28.6) | NS | 3 (37.5) | 4 (28.6) | NS |
| Heroin and/or fentanyl | 6 (60.0) | 7 (58.3) | NS | 4 (50.0) | 9 (64.3) | NS | 4 (50.0) | 9 (64.3) | NS |
| Methadone | 1 (10.0) | 1 (8.3) | NS | 1 (12.5) | 1 (7.1) | NS | 1 (12.5) | 1 (7.1) | NS |
| Enrolled in methadone treatment (yes) | 3 (25.0) | 3 (30.0) | NS | 2 (22.2) | 4 (30.8) | NS | 2 (25.0) | 4 (28.6) | NS |
| Preadmission methadone treatment dose (mg): median (IQR) | 30 (30, 70) | 60 (60, 155) | NS | 30 (30, 30) | 65 (60, 113) | NS | 30 (30, 30) | 65 (60, 113) | NS |
| Lifetime overdose history (yes) | 3 (30.0) | 6 (50.0) | NS | 1 (12.5) | 8(57.1) | NS | 1 (12.5) | 8(57.1) | NS |
| Methadone During Admission (yes) | 7 (70.0) | 10 (83.3) | NS | 5 (62.5) | 12 (85.7) | NS | 5 (62.5) | 12 (85.7) | NS |
| Continued from pre-admission | 3 (25) | 3 (30) | NS | 2 (22.2) | 4 (30.8) | NS | 2 (25.0) | 4 (28.6) | NS |
| Started during admission | 6 (50.0) | 5 (50.0) | NS | 4 (44.4) | 7 (53.9) | NS | 3 (37.5) | 8(57.1) | NS |
| Treatment-related characteristics | |||||||||
| Days admitted to hospital: median (IQR) | 12.5 (5.5,17.5) | 11 (5, 28.5) | NS | 12.5 (5, 17) | 11 (6, 18) | NS | 11 (5, 17) | 13 (6, 21) | NS |
| Reason for low-dose initiation | |||||||||
| Transition off methadone | 6 (60.0) | 8 (66.7) | NS | 4 (50.0) | 10 (71.4) | NS | 4 (50.0) | 10 (71.4) | NS |
| Transition off opioid analgesics | 2 (20.0) | 2 (16.7) | NS | 2 (25.0) | 2 (14.3) | NS | 2 (25.0) | 2 (14.3) | NS |
| History of precipitated withdrawal | 2 (20.0) | 3 (25.0) | NS | 2 (25.0) | 3 (21.4) | NS | 2 (25.0) | 2 (14.3) | NS |
| Low-dose initiation days: median (IQR) | 4.5 (4, 6) | 5 (2.5, 7.5) | NS | 4.5 (3, 6) | 5 (3, 7) | NS | 5 (3, 6) | 5 (3, 7) | NS |
| Highest COWS: median (IQR) | 1 (0, 8) | 1.5 (0, 9) | NS | 1 (1, 8) | 1.5 (0, 6) | NS | 2 (1, 8) | 2 (0, 6) | NS |
| Precipitated withdrawal (yes) | 2 (20.0) | 2 (16.7) | NS | 2 (25.0) | 2 (14.3) | NS | 2 (25.0) | 2 (14.3) | NS |
| Left hospital prior to completion (yes) | 4 (40.0) | 4 (33.3) | NS | 4 (50) | 4 (28.6) | NS | 4 (50.0) | 4 (28.6) | NS |
| Initiation completed as inpatient (yes) | 6 (60.0) | 3 (100) | NS | 4 (50.0) | 0 (0) | NS | 4 (50.0) | 5 (100.0) | NS |
| Opioids taken in 24 hrs prior | |||||||||
| Methadone | 5 (50.0) | 9 (75.0) | NS | 3 (37.5) | 11 (78.6) | NS | 3 (37.5) | 11 (78.6) | NS |
| Other opioids | 2 (20.0) | 2 (16.7) | NS | 2 (25.0) | 2 (14.3) | NS | 2 (25.0) | 2 (14.3) | NS |
| None | 3 (30.0) | 1 (8.3) | NS | 3 (37.5) | 1 (7.1) | NS | 3 (37.5) | 1 (7.1) | NS |
| Overlapping opioid | |||||||||
| Methadone | 5 (50.0) | 9 (75.0) | NS | 3 (21.4) | 11 (78.6) | NS | 3 (37.5) | 11 (78.6) | NS |
| Other opioids | 3 (30.0) | 3 (25.0) | NS | 3 (37.5) | 3 (21.4) | NS | 3 (37.5) | 3 (21.4) | NS |
| None | 2 (20.0) | 0 (0) | NS | 2 (25.0) | 0 (0) | NS | 2 (25.0) | 0 (0) | NS |
| Supplemental opioid MME: median (IQR) | 111 (8, 800) | 1907 (872, 3548) | 0.01 | 96 (3.8, 720) | 1640 (363, 2496) | 0.02 | 96 (4, 720) | 1640 (363, 2496) | 0.02 |
Bup, buprenorphine; IQR, interquartile range; SUD, substance use disorder; OUD, opioid use disorder; rx, prescription; COWS, Clinical Opiate Withdrawal Score; Bolded = statistically significant