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Dosing protocol for long-acting opioids
| Day | Buprenorphine dose | Full opioid agonist | ||
|---|---|---|---|---|
| Buccal buprenorphine film dose | SL bup-nx film dose | Total equivalent dose | ||
| 1 | 225 mcg once | 0.5 mg | Full dose | |
| 2 | 225 mcg BID | 1 mg | Full dose | |
| 3 | 450 mcg BID | 2 mg | Full dose | |
| 4 | 2 mg BID | 4 mg | Full dose | |
| 5 | 4 mg BID | 8 mg | Full dose | |
| 6 | 4 mg TID | 12 mg | Full dose | |
| 7 | 12 mg in the AM, 2–4 mg Q4H PRN | ≥12mg | STOP | |
SL, sublingual; bup-nx, buprenorphine-naloxone; BID, twice daily; TID, 3 times daily
